5'-O-(4,4'-dimethoxytrityl)-2'-O-(6-trifluoroacetamido)hexyluridine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(6-trifluoroacetamido)hexyluridine
• CAS No.: 912641-74-8
• Molecular Formula: C₃₈H₄₂F₃N₃O₉
• Molecular Weight: 741.761
• Mol file: 912641-74-8.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-(6-trifluoroacetamido)hexyluridine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(6-trifluoroacetamido)hexyluridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(6-trifluoroacetamido)hexyluridine

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-(6-trifluoroacetamido)hexyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl trifluoroacetate, (383-63-1) + 5'-O-(dimethoxytrityl)-2'-O-(hexylamino)uridine (165381-00-0) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-(6-trifluoroacetamido)hexyluridine (912641-74-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

1-iodo-6-(trifluoroacetamido)hexane (51224-10-3) + 4,4'-dimethoxytrityl chloride (40615-36-9) + 2,3’-O-dibutylstannyleneuridine (42822-78-6) → 5'-O-(4,4'-dimethoxytrityl)-3'-O-(6-trifluoroacetamido)hexyluridine + 5'-O-(4,4'-dimethoxytrityl)-2'-O-(6-trifluoroacetamido)hexyluridine (912641-74-8)

Guidance literature:

1-iodo-6-(trifluoroacetamido)hexane; 2,3’-O-dibutylstannyleneuridine; In N,N-dimethyl-formamide; for 18h; Heating;

4,4'-dimethoxytrityl chloride; With pyridine; dmap; In dichloromethane; at 20 ℃;

DOI:10.1081/NCN-200067400

Reference yield:

6-amino-1-hexanol (4048-33-3) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-(6-trifluoroacetamido)hexyluridine (912641-74-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 96 percent / CH₂Cl₂ / 5 h

2.1: 85 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

3.1: 85 percent / potassium iodide / acetone / 5 h / Heating

4.1: dimethylformamide / 18 h / Heating

4.2: 3.37 g / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

With pyridine; potassium iodide; In dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1081/NCN-200067400

upstream raw materials:

1-iodo-6-(trifluoroacetamido)hexane

4,4'-dimethoxytrityl chloride

2,3’-O-dibutylstannyleneuridine

6-amino-1-hexanol