3-Amino-(2S)-phenylsulfonylaminopropionicacid

Base Information

• Chemical Name: 3-Amino-(2S)-phenylsulfonylaminopropionicacid
• CAS No.: 156185-88-5
• Molecular Formula: C9H12 N2 O4 S
• Molecular Weight: 244.271
• Mol file: 156185-88-5.mol

Synonyms:3-Amino-(2S)-phenylsulfonylaminopropionicacid;3-AMINO-(2S)-PHENYLSULPHONYLAMINO-PROPIONIC ACID

Chemical Property of 3-Amino-(2S)-phenylsulfonylaminopropionicacid

Chemical Property:

• Boiling Point: 465.9±55.0 °C(Predicted)
• PKA: 2.36±0.16(Predicted)
• PSA: 117.87000
• Density: 1.422±0.06 g/cm3(Predicted)
• LogP: 1.54880

Purity/Quality:

98%Min ^*data from raw suppliers

3-AMINO-(2S)-PHENYLSULFONYLAMINOPROPIONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-(2S)-phenylsulfonylaminopropionicacid

There total 4 articles about 3-Amino-(2S)-phenylsulfonylaminopropionicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-phenylsulfonyl-L-asparagine (156185-87-4) → 3-amino-2(S)-phenylsulfonylaminopropionic acid (156185-88-5)

Guidance literature:

With sodium hydroxide; bromine; In water; at 0 - 90 ℃;

DOI:10.1016/S0968-0896(98)00090-X

Reference yield:

Nα-benzenesulfonyl-L-asparagine (402579-11-7) → 3-amino-2(S)-phenylsulfonylaminopropionic acid (156185-88-5)

Guidance literature:

With hydrogenchloride; sodium hydroxide; bromine; In water;

Reference yield:

benzenesulfonyl chloride (98-09-9) → 3-amino-2(S)-phenylsulfonylaminopropionic acid (156185-88-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / aq. NaOH / dioxane / 0.5 h / 0 °C

2: 24 percent / aq. NaOH; Br₂ / 0.83 h / 0 - 90 °C

With sodium hydroxide; bromine; In 1,4-dioxane; 1: Condensation / 2: Hofmann degradation;

DOI:10.1021/jm000133v

upstream raw materials:

N-phenylsulfonyl-L-asparagine

benzenesulfonyl chloride

Nα-benzenesulfonyl-L-asparagine

Downstream raw materials:

tert-butyl (2S)-N-benzenesulfonyl-2,3-diaminopropionate

(S)-3-[4-(2-Amino-ethoxy)-benzoylamino]-2-benzenesulfonylamino-propionic acid

3-{4-[2-(pyrimidin-2-ylamino)ethyloxy]benzoylamino}-2(S)-benzenesulfonylaminopropionic acid

3-{4-[2-(pyrimidin-2-ylamino)ethyloxy]benzoylamino}-2(S)-benzenesulfonylaminopropionic acid tert-butyl ester