(2E)-1-[7-(butylamino)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-3-(dimethylamino)-2-propen-1-one

Base Information

Chemical Name:(2E)-1-[7-(butylamino)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-3-(dimethylamino)-2-propen-1-one
CAS No.:437612-88-9
Molecular Formula:C₂₂H₂₅FN₄O
Molecular Weight:380.465
Hs Code.:

Synonyms:(2E)-1-[7-(butylamino)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-3-(dimethylamino)-2-propen-1-one

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Chemical Property of (2E)-1-[7-(butylamino)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-3-(dimethylamino)-2-propen-1-one

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Technology Process of (2E)-1-[7-(butylamino)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-3-(dimethylamino)-2-propen-1-one

There total 3 articles about (2E)-1-[7-(butylamino)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-3-(dimethylamino)-2-propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 437612-87-8
1-[7-(butylamino)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]ethanone

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 437612-88-9
(2E)-1-[7-(butylamino)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-3-(dimethylamino)-2-propen-1-one

Guidance literature:: for 144h; Heating;
DOI:10.1016/j.bmc.2005.05.043

Reference yield:

: 437384-08-2
1-[7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]ethanone

: 437612-88-9
(2E)-1-[7-(butylamino)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-3-(dimethylamino)-2-propen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / rac-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; cesium carbonate / palladium(II) acetate / toluene / 100 °C

2: 95 percent / 144 h / Heating

With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In toluene; 1: Buchwald-Hartwig amination;
DOI:10.1016/j.bmc.2005.05.043

Reference yield:

: 437384-07-1
7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine

: 437612-88-9
(2E)-1-[7-(butylamino)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-3-(dimethylamino)-2-propen-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / BF₃*OEt₂ / toluene / 3.5 h / Heating

2: (+/-)-BINAP; Cs₂CO₃; Pd(OAc)2 / toluene / 95 °C

3: Heating

With palladium diacetate; boron trifluoride diethyl etherate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; 1: Friedel-Crafts acylation;
DOI:10.1016/j.bmc.2005.01.044