4'-dibenzylamino-4''-fluoro-[1,1';3',1'']terphenyl-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4'-dibenzylamino-4''-fluoro-[1,1';3',1'']terphenyl-4-carboxylic acid ethyl ester
• CAS No.: 1266679-93-9
• Molecular Formula: C₃₅H₃₀FNO₂
• Molecular Weight: 515.627
• Mol file: 1266679-93-9.mol

Synonyms:4'-dibenzylamino-4''-fluoro-[1,1';3',1'']terphenyl-4-carboxylic acid ethyl ester

Chemical Property of 4'-dibenzylamino-4''-fluoro-[1,1';3',1'']terphenyl-4-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-dibenzylamino-4''-fluoro-[1,1';3',1'']terphenyl-4-carboxylic acid ethyl ester

There total 2 articles about 4'-dibenzylamino-4''-fluoro-[1,1';3',1'']terphenyl-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-fluoro-2,4,6-trimethyldiphenyliodonium trifluoromethanesulfonate (1146127-04-9) + 4'-dibenzylamino-biphenyl-4-carboxylic acid ethyl ester (1266679-92-8) → 4'-dibenzylamino-4''-fluoro-[1,1';3',1'']terphenyl-4-carboxylic acid ethyl ester (1266679-93-9)

Guidance literature:

4-fluoro-2,4,6-trimethyldiphenyliodonium trifluoromethanesulfonate; 4'-dibenzylamino-biphenyl-4-carboxylic acid ethyl ester; With copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 70 ℃; for 9h;

With sodium hydrogencarbonate; In dichloromethane; water; regioselective reaction; Saturated solution;

DOI:10.1002/anie.201004703

Reference yield:

N,N-dibenzylaniline (91-73-6) + [4-(ethoxycarbonyl)phenyl](2,4,6-trimethylphenyl)iodonium trifluoromethanesulfonate (1204518-04-6) → 4'-dibenzylamino-4''-fluoro-[1,1';3',1'']terphenyl-4-carboxylic acid ethyl ester (1266679-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 2,6-di-tert-butyl-pyridine; copper(II) bis(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 20 h / 50 °C

1.2: Saturated solution

2.1: copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 9 h / 70 °C

2.2: Saturated solution

With 2,6-di-tert-butyl-pyridine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1002/anie.201004703

upstream raw materials:

N,N-dibenzylaniline

[4-(ethoxycarbonyl)phenyl](2,4,6-trimethylphenyl)iodonium trifluoromethanesulfonate

4-fluoro-2,4,6-trimethyldiphenyliodonium trifluoromethanesulfonate

4'-dibenzylamino-biphenyl-4-carboxylic acid ethyl ester