61274-13-3

Basic information

• Product Name: 2,5-Pyrrolidinedione, 1-[(cyclohexylcarbonyl)oxy]-
• CAS NO: 61274-13-3
• Molecular Formula: C11H15NO4
• Molecular Weight: 225.244
• Mol File: 61274-13-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2,5-Pyrrolidinedione, 1-[(cyclohexylcarbonyl)oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Pyrrolidinedione, 1-[(cyclohexylcarbonyl)oxy]-(61274-13-3)
• EPA Substance Registry System: 2,5-Pyrrolidinedione, 1-[(cyclohexylcarbonyl)oxy]-(61274-13-3)

Safety Data

• Hazardous Substances Data: 61274-13-3(Hazardous Substances Data)

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 2043-61-0 cyclohexanecarbaldehyde 
• 98-89-5 Cyclohexanecarboxylic acid 

Downstream Products

• 13810-02-1 N-hydroxycyclohexanecarboxamide 
• 130340-71-5 N-(p-methylbenzyl)cyclohexanecarboxamide 
• 1369515-43-4 N-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)tetrahydro-2H-pyran-4-carboxamide 
• 1072896-46-8 p-methoxyphenyl (9-cyclohexanecarboxamido-3,5,9-trideoxy-5-glycolamido-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-β-D-galactopyranoside 
• 1000991-62-7 C₁₆H₂₁NO₄ 

Relevant articles and documents

Argininamide-type neuropeptide y Y1 receptor antagonists: The nature of: N Ω-carbamoyl substituents determines Y1R binding mode and affinity

The recently resolved crystal structure of the neuropeptide Y Y1 receptor (Y1R), co-crystallized with the high-affinity (pKi: 10.11), argininamide-type Y1R antagonist UR-MK299 (2), revealed that the NΩ-carbamoyl substituent (van der Waals volume: 139 ?3) is deeply buried in the receptor, occupying a hydrophobic pocket. We synthesized and characterized a series of argininamides, structurally related to 2. Y1R affinity decreased with increasing size of the carbamoyl residue (minimal pKi: 5.67). Exceeding a critical size of the substituent (van der Waals volume: 212 ?3), the ligands bound in an inverted mode with the carbamoyl side chain located at the surface of the receptor, as suggested by induced-fit docking and MD simulations.

An efficient procedure for the preparation of carboxamides and peptides using in situ generated N-succinimidyl active esters

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Aerobic amide bond formation with N-hydroxysuccinimide

Breathe easy: Molecular oxygen is one of the most abundant, atom-efficient, and economical oxidants. An aerobic oxidative amide formation from aldehydes and amines is reported. The method uses a catalytic amount of Co(OAc) 2 and N-hydroxysuccinimide as reaction promoters. It is applicable to chiral substrates without loss of their optical purity. Copyright