1-[(Cyclohexanecarbonyl)oxy]pyrrolidine-2,5-dione

Base Information

• Chemical Name: 1-[(Cyclohexanecarbonyl)oxy]pyrrolidine-2,5-dione
• CAS No.: 61274-13-3
• Molecular Formula: C11H15NO4
• Molecular Weight: 225.244
• DSSTox Substance ID: DTXSID20596218
• Nikkaji Number: J2.328.820F
• Wikidata: Q82491421
• Mol file: 61274-13-3.mol

Synonyms:61274-13-3;1-[(Cyclohexanecarbonyl)oxy]pyrrolidine-2,5-dione;(2,5-dioxopyrrolidin-1-yl) cyclohexanecarboxylate;SCHEMBL1421902;DTXSID20596218;cyclohexanecarboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Chemical Property of 1-[(Cyclohexanecarbonyl)oxy]pyrrolidine-2,5-dione

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 225.10010796
• Heavy Atom Count: 16
• Complexity: 304

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)C(=O)ON2C(=O)CCC2=O

Technology Process of 1-[(Cyclohexanecarbonyl)oxy]pyrrolidine-2,5-dione

There total 3 articles about 1-[(Cyclohexanecarbonyl)oxy]pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Cyclohexanecarboxylic acid (98-89-5) → succinimidyl cyclohexanecarboxylate (61274-13-3)

Guidance literature:

Cyclohexanecarboxylic acid; With bis(trichloromethyl) carbonate; triethylamine; In dichloromethane; at 0 ℃;

1-hydroxy-pyrrolidine-2,5-dione; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1080/00397910902906628

Reference yield:

cyclohexanecarbaldehyde (2043-61-0) → succinimidyl cyclohexanecarboxylate (61274-13-3)

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; oxygen; cobalt(II) diacetate tetrahydrate; sodium hydrogencarbonate; In acetonitrile; at 20 ℃; for 1h; under 760.051 Torr; Molecular sieve;

DOI:10.1002/asia.201200017

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + cyclohexanecarbaldehyde (2043-61-0) → succinimidyl cyclohexanecarboxylate (61274-13-3)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In acetonitrile; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1002/adsc.201400188

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Cyclohexanecarboxylic acid

cyclohexanecarbaldehyde

Downstream raw materials:

C₁₆H₂₁NO₄

p-methoxyphenyl (9-cyclohexanecarboxamido-3,5,9-trideoxy-5-glycolamido-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-β-D-galactopyranoside

N-(p-methylbenzyl)cyclohexanecarboxamide

N-hydroxycyclohexanecarboxamide