1-(2-bromo-4-nitrophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane

Base Information

• Chemical Name: 1-(2-bromo-4-nitrophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane
• CAS No.: 177597-24-9
• Molecular Formula: C₁₉H₂₃BrN₂O₅
• Molecular Weight: 439.306
• Mol file: 177597-24-9.mol

Synonyms:1-(2-bromo-4-nitrophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane

Chemical Property of 1-(2-bromo-4-nitrophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-bromo-4-nitrophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane

There total 3 articles about 1-(2-bromo-4-nitrophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-4-nitrophenol (5847-59-6) → 1-(2-bromo-4-nitrophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane (177597-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 85 °C

2: acetonitrile; ethanol / Heating

With potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0960-894X(98)00689-1

Reference yield:

stannous chloride (7772-99-8) + 1-(2-bromo-4-aminophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane (177597-25-0) → 1-(2-bromo-4-nitrophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane (177597-24-9)

Guidance literature:

With hydrogenchloride; potassium carbonate; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

Reference yield:

N-methylhomoveratrylamine (3490-06-0) + 2-bromo-1-(2-bromoethoxy)-4-nitrobenzene (177597-23-8) → 1-(2-bromo-4-nitrophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane (177597-24-9)

Guidance literature:

In ethanol; acetonitrile; Heating;

DOI:10.1016/S0960-894X(98)00689-1

upstream raw materials:

N-methylhomoveratrylamine

2-bromo-1-(2-bromoethoxy)-4-nitrobenzene

2-bromo-4-nitrophenol

stannous chloride

Downstream raw materials:

1-(2-bromo-4-aminophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane