3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide

Base Information

• Chemical Name: 3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide
• CAS No.: 1126642-78-1
• Molecular Formula: C₁₆H₁₉N₅O
• Molecular Weight: 297.36
• Mol file: 1126642-78-1.mol

Synonyms:3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide

Chemical Property of 3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide

There total 7 articles about 3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

(1H-imidazol-1-yl)(3,5,6-trimethylpyrazin-2-yl)methanone (1415910-56-3) + 1-(4-tolyl)guanidine (54015-04-2) → 3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide (1126642-78-1)

Guidance literature:

at 20 ℃; for 5h;

DOI:10.2174/157340612802084243

Reference yield:

2-Pyrazinemethanol,3,5,6-trimethyl (75907-74-3) → 3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide (1126642-78-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium permanganate / water / 0.67 h / 20 °C

2: 1,4-dioxane; N,N-dimethyl-formamide / 2 h

3: 5 h / 20 °C

With potassium permanganate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.2174/157340612802084243

Reference yield:

Tetramethylpyrazine (1124-11-4) → 3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide (1126642-78-1)

Guidance literature:

Multi-step reaction with 6 steps

1: dihydrogen peroxide; acetic acid

3: sodium hydroxide

4: potassium permanganate / water / 0.67 h / 20 °C

5: 1,4-dioxane; N,N-dimethyl-formamide / 2 h

6: 5 h / 20 °C

With potassium permanganate; dihydrogen peroxide; acetic acid; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.2174/157340612802084243

upstream raw materials:

Tetramethylpyrazine

2,3,5,6-tetramethylpyrazine mono N-oxide

(3,5,6-trimethylpyrazin-2-yl)methyl acetate

p-tolylguanidine carbonate