(R)-3-phenyl-1-(5-methoxy-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

Base Information

• Chemical Name: (R)-3-phenyl-1-(5-methoxy-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline
• CAS No.: 1383456-30-1
• Molecular Formula: C₃₁H₂₆N₂O₃S
• Molecular Weight: 506.625

Synonyms:(R)-3-phenyl-1-(5-methoxy-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

Chemical Property of (R)-3-phenyl-1-(5-methoxy-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

Chemical Property:

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Technology Process of (R)-3-phenyl-1-(5-methoxy-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

There total 8 articles about (R)-3-phenyl-1-(5-methoxy-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

o-(phenylethynyl)benzaldehyde (59046-72-9) → 1-methyl-3-phenylisoquinoline (1721-96-6) + (R)-1-(1H-indol-3-yl)-3-phenyl-2-tosyl-1,2-dihydroisoquinoline (1383456-23-2) + (R)-3-phenyl-1-(5-methoxy-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline (1383456-30-1) + (Z)-1-benzylidene-3-(phenylethynyl)-1,3-dihydroisobenzofuran (1394324-93-6) + (S)-1-(1H-indol-3-yl)-3-phenyl-2-tosyl-1,2-dihydroisoquinoline + 1-methyl-3-phenylisoquinoline-2-oxide (1202458-12-5)

Guidance literature:

Inert atmosphere;

DOI:10.1021/jo302524a

Reference yield: 88.0%

o-(phenylethynyl)benzaldehyde (59046-72-9) → 1-methyl-3-phenylisoquinoline (1721-96-6) + (R)-1-(1H-indol-3-yl)-3-phenyl-2-tosyl-1,2-dihydroisoquinoline (1383456-23-2) + (R)-3-phenyl-1-(5-methoxy-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline (1383456-30-1) + (Z)-1-benzylidene-3-(phenylethynyl)-1,3-dihydroisobenzofuran (1394324-93-6) + (S)-1-(1H-indol-3-yl)-3-phenyl-2-tosyl-1,2-dihydroisoquinoline + 1-methyl-3-phenylisoquinoline-2-oxide (1202458-12-5) + (S)-3-phenyl-1-(5-methoxy-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline + phenyl(2-phenyl-3-(tributylstannyl)naphthalen-1-yl)methanone (1394324-92-5)

Guidance literature:

Inert atmosphere;

DOI:10.1021/jo302524a

Reference yield: 88.0%

o-(phenylethynyl)benzaldehyde (59046-72-9) → 1-methyl-3-phenylisoquinoline (1721-96-6) + (R)-1-(1H-indol-3-yl)-3-phenyl-2-tosyl-1,2-dihydroisoquinoline (1383456-23-2) + (R)-3-phenyl-1-(5-methoxy-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline (1383456-30-1) + (Z)-1-benzylidene-3-(phenylethynyl)-1,3-dihydroisobenzofuran (1394324-93-6) + (S)-1-(1H-indol-3-yl)-3-phenyl-2-tosyl-1,2-dihydroisoquinoline + 1-methyl-3-phenylisoquinoline-2-oxide (1202458-12-5) + (S)-3-phenyl-1-(5-methoxy-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline + phenyl(2-phenyl-3-(tributylstannyl)naphthalen-1-yl)methanone (1394324-92-5) + (R)-3-phenyl-1-(1-methyl-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline (1383456-32-3) + (S)-3-phenyl-1-(1-methyl-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

Guidance literature:

Inert atmosphere;

DOI:10.1021/jo302524a

upstream raw materials:

5-methoxylindole

o-(phenylethynyl)benzaldehyde

phenylacetylene

ortho-bromobenzaldehyde

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