(R)-benzyl 4-(3-amino-2-fluorobenzyl)-2-methylpiperazine-1-carboxylate

Base Information

• Chemical Name: (R)-benzyl 4-(3-amino-2-fluorobenzyl)-2-methylpiperazine-1-carboxylate
• CAS No.: 942224-50-2
• Molecular Formula: C₂₀H₂₄FN₃O₂
• Molecular Weight: 357.428
• Mol file: 942224-50-2.mol

Synonyms:(R)-benzyl 4-(3-amino-2-fluorobenzyl)-2-methylpiperazine-1-carboxylate

Chemical Property of (R)-benzyl 4-(3-amino-2-fluorobenzyl)-2-methylpiperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (R)-benzyl 4-(3-amino-2-fluorobenzyl)-2-methylpiperazine-1-carboxylate

There total 1 articles about (R)-benzyl 4-(3-amino-2-fluorobenzyl)-2-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C7H6FNO (873697-69-9) + phenylmethyl (2R)-2-methyl-1-piperazinecarboxylate (923565-99-5,923565-98-4) → (R)-benzyl 4-(3-amino-2-fluorobenzyl)-2-methylpiperazine-1-carboxylate (942224-50-2)

Guidance literature:

C₇H₆FNO; phenylmethyl (2R)-2-methyl-1-piperazinecarboxylate; With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 1.5h;

With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield: 71.0%

5-isocyanato-2-methylpyridine (732245-99-7) + (R)-benzyl 4-(3-amino-2-fluorobenzyl)-2-methylpiperazine-1-carboxylate (942224-50-2) → (R)-benzyl 4-(2-fluoro-3-(3-(6-methylpyridin-3-yl)ureido)benzyl)-2-methylpiperazine-1-carboxylate

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 27.0%

3-methyl-4-pyridinamine (18437-58-6) + (R)-benzyl 4-(3-amino-2-fluorobenzyl)-2-methylpiperazine-1-carboxylate (942224-50-2) + bis(trichloromethyl) carbonate (32315-10-9) → (R)-benzyl 4-(2-fluoro-3-(3-(2-methylpyridin-4-yl)ureido)benzyl)-2-methylpiperazine-1-carboxylate

Guidance literature:

(R)-benzyl 4-(3-amino-2-fluorobenzyl)-2-methylpiperazine-1-carboxylate; bis(trichloromethyl) carbonate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 0.583333h;

3-methyl-4-pyridinamine; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

C₇H₆FNO

phenylmethyl (2R)-2-methyl-1-piperazinecarboxylate