methyl 4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzimidate hydrochloride

Base Information

• Chemical Name: methyl 4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzimidate hydrochloride
• CAS No.: 1001013-61-1
• Molecular Formula: C₁₅H₁₃N₃O*ClH
• Molecular Weight: 287.749
• Mol file: 1001013-61-1.mol

Synonyms:methyl 4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzimidate hydrochloride

Chemical Property of methyl 4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzimidate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of methyl 4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzimidate hydrochloride

There total 3 articles about methyl 4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzimidate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzonitrile (1001013-59-7) → methyl 4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzimidate hydrochloride (1001013-61-1)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 - 20 ℃; for 5.33333h;

Reference yield:

7-Azaindole (271-63-6) → methyl 4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzimidate hydrochloride (1001013-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate / copper(l) iodide; trans-1,2-Diaminocyclohexane / 1,4-dioxane / 19 h / 120 °C

2: hydrogenchloride / diethyl ether / 5.33 h / 0 - 20 °C

With hydrogenchloride; potassium phosphate; copper(l) iodide; trans-1,2-Diaminocyclohexane; In 1,4-dioxane; diethyl ether;

Reference yield:

4-iodobenzonitrile (3058-39-7) → methyl 4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzimidate hydrochloride (1001013-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate / copper(l) iodide; trans-1,2-Diaminocyclohexane / 1,4-dioxane / 19 h / 120 °C

2: hydrogenchloride / diethyl ether / 5.33 h / 0 - 20 °C

With hydrogenchloride; potassium phosphate; copper(l) iodide; trans-1,2-Diaminocyclohexane; In 1,4-dioxane; diethyl ether;

upstream raw materials:

4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzonitrile

7-Azaindole

4-iodobenzonitrile

Downstream raw materials:

(E)-4-(1H-pyrrolo[2,3-b]pyridin-1-yl)-N'-(thiazol-2-yl)benzamidine

Refernces