diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonate

Base Information

Chemical Name:diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonate
CAS No.:1428527-60-9
Molecular Formula:C₂₈H₃₀N₅O₆P
Molecular Weight:563.55
Hs Code.:

Synonyms:diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonate

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Chemical Property of diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonate

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Technology Process of diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonate

There total 10 articles about diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1187992-93-3
4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxylic acid

: 1428527-59-6
diethyl 4-(amino(4-methoxyphenyl)methyl)benzylphosphonate

: 1428527-60-9
diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 50 ℃; for 2h; Inert atmosphere;

Reference yield:

: 100-66-3
methoxybenzene

: 1428527-60-9
diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonate

Guidance literature:: Multi-step reaction with 6 steps

1: aluminum (III) chloride / dichloromethane / 10 h / 20 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Reflux

3: N,N-dimethyl-formamide / 10 h / 150 °C

4: hydroxylamine hydrochloride; sodium carbonate / ethanol / 10 h / Reflux

5: hydrogen / ethanol / 12 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

With aluminum (III) chloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 1428527-60-9
diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonate

Guidance literature:: Multi-step reaction with 6 steps

1: aluminum (III) chloride / dichloromethane / 10 h / 20 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Reflux

3: N,N-dimethyl-formamide / 10 h / 150 °C

4: hydroxylamine hydrochloride; sodium carbonate / ethanol / 10 h / Reflux

5: hydrogen / ethanol / 12 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

With aluminum (III) chloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;