4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonic acid

Base Information

Chemical Name:4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonic acid
CAS No.:1428527-61-0
Molecular Formula:C₂₄H₂₂N₅O₆P
Molecular Weight:507.442
Hs Code.:

Synonyms:4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonic acid

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Chemical Property of 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonic acid

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Technology Process of 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonic acid

There total 11 articles about 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1428527-60-9
diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonate

: 1428527-61-0
4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonic acid

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 14h;

Reference yield:

: 100-66-3
methoxybenzene

: 1428527-61-0
4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonic acid

Guidance literature:: Multi-step reaction with 7 steps

1: aluminum (III) chloride / dichloromethane / 10 h / 20 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Reflux

3: N,N-dimethyl-formamide / 10 h / 150 °C

4: hydroxylamine hydrochloride; sodium carbonate / ethanol / 10 h / Reflux

5: hydrogen / ethanol / 12 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

7: trimethylsilyl bromide / dichloromethane / 14 h / 20 °C

With aluminum (III) chloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); trimethylsilyl bromide; hydroxylamine hydrochloride; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 1428527-61-0
4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonic acid

Guidance literature:: Multi-step reaction with 7 steps

1: aluminum (III) chloride / dichloromethane / 10 h / 20 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Reflux

3: N,N-dimethyl-formamide / 10 h / 150 °C

4: hydroxylamine hydrochloride; sodium carbonate / ethanol / 10 h / Reflux

5: hydrogen / ethanol / 12 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

7: trimethylsilyl bromide / dichloromethane / 14 h / 20 °C

With aluminum (III) chloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); trimethylsilyl bromide; hydroxylamine hydrochloride; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;