(1R,5R)-(Z)-3-bromomethylene-5-(tert-butyldimethyl-silanyloxy)cyclohexanol

Base Information

• Chemical Name: (1R,5R)-(Z)-3-bromomethylene-5-(tert-butyldimethyl-silanyloxy)cyclohexanol
• CAS No.: 387834-44-8
• Molecular Formula: C₁₃H₂₅BrO₂Si
• Molecular Weight: 321.33

Synonyms:(1R,5R)-(Z)-3-bromomethylene-5-(tert-butyldimethyl-silanyloxy)cyclohexanol

Chemical Property of (1R,5R)-(Z)-3-bromomethylene-5-(tert-butyldimethyl-silanyloxy)cyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,5R)-(Z)-3-bromomethylene-5-(tert-butyldimethyl-silanyloxy)cyclohexanol

There total 1 articles about (1R,5R)-(Z)-3-bromomethylene-5-(tert-butyldimethyl-silanyloxy)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(1R,4R,6S)-(E)-2-bromomethylene-4-(tert-butyldimethylsilyloxy)-7-oxa-bicyclo[4.1.0]heptane (387834-43-7) → (1R,5R)-(Z)-3-bromomethylene-5-(tert-butyldimethyl-silanyloxy)cyclohexanol (387834-44-8)

Guidance literature:

With diisobutylaluminium hydride; In hexane; at 0 ℃; for 1.5h;

DOI:10.1021/ol016908r

Reference yield: 96.0%

ethylmagnesium bromide (925-90-6) + (1R,5R)-(Z)-3-bromomethylene-5-(tert-butyldimethyl-silanyloxy)cyclohexanol (387834-44-8) + (R)-10-[(E)-5,5-dimethyl-[1,3,2]dioxaborolan-2-yl]-5-methyldec-9-enoic acid ethyl ester (387834-50-6) → (1R,3R)-5-[(S)-(E)-11-ethyl-11-hydroxy-7-methyltridec-2-enylidene]cyclohexane-1,3-diol

Guidance literature:

Multistep reaction.;

DOI:10.1021/ol016908r

Reference yield: 94.0%

methylmagnesium chloride (676-58-4) + (1R,5R)-(Z)-3-bromomethylene-5-(tert-butyldimethyl-silanyloxy)cyclohexanol (387834-44-8) + (R)-10-[(E)-5,5-dimethyl-[1,3,2]dioxaborolan-2-yl]-5-methyldec-9-enoic acid ethyl ester (387834-50-6) → (1R,3R)-5-[(R)-(E)-11-hydroxy-7,11-dimethyldodec-2-enylidene]cyclohexane-1,3-diol

Guidance literature:

Multistep reaction.;

DOI:10.1021/ol016908r

upstream raw materials:

(1R,4R,6S)-(E)-2-bromomethylene-4-(tert-butyldimethylsilyloxy)-7-oxa-bicyclo[4.1.0]heptane

Downstream raw materials:

(3R,5R)-1-bromomethylene-3,5-bis-(tert-butyldimethylsilanyloxy)cyclohexane

(3R,5R)-2-[3,5-bis-(tert-butyldimethylsilanyloxy)cyclohexylidenemethyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

(1R,3R)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-5-((E)-(R)-7,11-dimethyl-11-triethylsilanyloxy-dodec-2-enylidene)-cyclohexane

(1R,3aS,7aR)-4-[2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-7a-methyl-octahydro-indene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 387834-44-8 (1R,5R)-(Z)-3-bromomethylene-5-(tert-butyldimethyl-silanyloxy)cyclohexanol

Send

Send

Metric Ton KG G Pound L ML

Send

Send