(2R)-2-hydroxy-3-(phenylseleno)propylbutyrate

Base Information

• Chemical Name: (2R)-2-hydroxy-3-(phenylseleno)propylbutyrate
• CAS No.: 702711-08-8
• Molecular Formula: C₁₃H₁₈O₃Se
• Molecular Weight: 301.244
• Mol file: 702711-08-8.mol

Synonyms:(2R)-2-hydroxy-3-(phenylseleno)propylbutyrate

Chemical Property of (2R)-2-hydroxy-3-(phenylseleno)propylbutyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-hydroxy-3-(phenylseleno)propylbutyrate

There total 1 articles about (2R)-2-hydroxy-3-(phenylseleno)propylbutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

diphenyl diselenide (1666-13-3) + (S)-2,3-dihydroxypropyl butyrate (126254-87-3) → (2R)-3-(phenylseleno)propane-1,2-diol (744198-92-3) + (2R)-2-hydroxy-3-(phenylseleno)propylbutyrate (702711-08-8)

Guidance literature:

diphenyl diselenide; With sodium hydride; In tetrahydrofuran; for 2h; Heating;

(S)-2,3-dihydroxypropyl butyrate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at 20 ℃; for 1h; Further stages.;

DOI:10.1002/chem.200305497

Reference yield: 67.0%

benzoyl isocyanate (4461-33-0) + (2R)-2-hydroxy-3-(phenylseleno)propylbutyrate (702711-08-8) → (2R)-2-{[(benzoylamino)carbonyl]oxy}-3-(phenylseleno)propyl butyrate (702711-17-9)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1002/chem.200305497

Reference yield:

(2R)-2-hydroxy-3-(phenylseleno)propylbutyrate (702711-08-8) → C21H23NO6Se

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / CH₂Cl₂ / 20 °C

2: potassium hydrogenphosphate; m-chloroperoxybenzoic acid / tetrahydrofuran / 2 h

With dipotassium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1002/chem.200305497

upstream raw materials:

diphenyl diselenide

(S)-2,3-dihydroxypropyl butyrate

Downstream raw materials:

(2R)-2-{[(benzoylamino)carbonyl]oxy}-3-(phenylseleno)propyl butyrate