(3R,4S)-4-hydroxy-4-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)methyl-N,N-diethylbutanamide

Base Information

Chemical Name:(3R,4S)-4-hydroxy-4-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)methyl-N,N-diethylbutanamide
CAS No.:566949-62-0
Molecular Formula:C₂₆H₄₇NO₅Si
Molecular Weight:481.748
Hs Code.:

Synonyms:(3R,4S)-4-hydroxy-4-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)methyl-N,N-diethylbutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S)-4-hydroxy-4-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)methyl-N,N-diethylbutanamide

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Technology Process of (3R,4S)-4-hydroxy-4-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)methyl-N,N-diethylbutanamide

There total 2 articles about (3R,4S)-4-hydroxy-4-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)methyl-N,N-diethylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 109-89-7
diethylamine

: 566949-61-9
(3R)-3-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

: 566949-62-0
(3R,4S)-4-hydroxy-4-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)methyl-N,N-diethylbutanamide

Guidance literature:: With trimethylaluminum; In hexane; dichloromethane; at 20 ℃; for 16h;
DOI:10.1039/b211801g

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 566949-62-0
(3R,4S)-4-hydroxy-4-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)methyl-N,N-diethylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

2: 85 percent / AlMe₃ / CH₂Cl₂; hexane / 16 h / 20 °C

With 2,6-dimethylpyridine; trimethylaluminum; In hexane; dichloromethane;
DOI:10.1039/b211801g