6-(4,5-dihydro-1H-imidazol-2-yl)-3-(4-trifluoromethyl-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one

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Chemical Name:6-(4,5-dihydro-1H-imidazol-2-yl)-3-(4-trifluoromethyl-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one
CAS No.:1518920-19-8
Molecular Formula:C₁₇H₁₃F₃N₄O
Molecular Weight:346.312
Hs Code.:

Synonyms:6-(4,5-dihydro-1H-imidazol-2-yl)-3-(4-trifluoromethyl-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one

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Chemical Property of 6-(4,5-dihydro-1H-imidazol-2-yl)-3-(4-trifluoromethyl-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one

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Technology Process of 6-(4,5-dihydro-1H-imidazol-2-yl)-3-(4-trifluoromethyl-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one

There total 5 articles about 6-(4,5-dihydro-1H-imidazol-2-yl)-3-(4-trifluoromethyl-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1518920-10-9
1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbonitrile

: 107-15-3,85404-18-8
ethylenediamine

: 1518920-19-8
6-(4,5-dihydro-1H-imidazol-2-yl)-3-(4-trifluoromethyl-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one

Guidance literature:: With tetraphosphorus decasulfide; at 120 ℃; for 2h; Sealed tube;

Reference yield:

: 1518920-27-8
6-bromo-3-(4-trifluoromethylphenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one

: 1518920-19-8
6-(4,5-dihydro-1H-imidazol-2-yl)-3-(4-trifluoromethyl-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere; Sealed tube

1.2: 1 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

2.1: tetraphosphorus decasulfide / 2 h / 120 °C / Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetraphosphorus decasulfide; XPhos; In N,N-dimethyl-formamide;

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1518920-19-8
6-(4,5-dihydro-1H-imidazol-2-yl)-3-(4-trifluoromethyl-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: ammonium acetate; acetic acid / 130 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere; Sealed tube

3.2: 1 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

4.1: tetraphosphorus decasulfide / 2 h / 120 °C / Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetraphosphorus decasulfide; ammonium acetate; potassium carbonate; acetic acid; XPhos; In N,N-dimethyl-formamide;