(2R)-2-{[N,N-di(4-fluorophenyl)-carbamoyloxy]methyl}-5-[(ethoxycarbonyl)methoxy]-2-hydroxy-1,2,3,4-tetrahydronaphthalene

Base Information

Chemical Name:(2R)-2-{[N,N-di(4-fluorophenyl)-carbamoyloxy]methyl}-5-[(ethoxycarbonyl)methoxy]-2-hydroxy-1,2,3,4-tetrahydronaphthalene
CAS No.:227951-71-5
Molecular Formula:C₂₈H₂₇F₂NO₆
Molecular Weight:511.522
Hs Code.:

Synonyms:(2R)-2-{[N,N-di(4-fluorophenyl)-carbamoyloxy]methyl}-5-[(ethoxycarbonyl)methoxy]-2-hydroxy-1,2,3,4-tetrahydronaphthalene

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Chemical Property of (2R)-2-{[N,N-di(4-fluorophenyl)-carbamoyloxy]methyl}-5-[(ethoxycarbonyl)methoxy]-2-hydroxy-1,2,3,4-tetrahydronaphthalene

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Technology Process of (2R)-2-{[N,N-di(4-fluorophenyl)-carbamoyloxy]methyl}-5-[(ethoxycarbonyl)methoxy]-2-hydroxy-1,2,3,4-tetrahydronaphthalene

There total 6 articles about (2R)-2-{[N,N-di(4-fluorophenyl)-carbamoyloxy]methyl}-5-[(ethoxycarbonyl)methoxy]-2-hydroxy-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R)-2-{[N,N-di(4-fluorophenyl)carbamoyloxy]methyl}-2,5-dihydroxy-1,2,3,4-tetrahydronaphthalene

: 105-36-2
ethyl bromoacetate

: 227951-71-5
(2R)-2-{[N,N-di(4-fluorophenyl)-carbamoyloxy]methyl}-5-[(ethoxycarbonyl)methoxy]-2-hydroxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 896127-56-3
N,N-bis-(4-fluoro-phenyl)-acetamide

: 227951-71-5
(2R)-2-{[N,N-di(4-fluorophenyl)-carbamoyloxy]methyl}-5-[(ethoxycarbonyl)methoxy]-2-hydroxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH / ethanol

2: pyridine / CH₂Cl₂

3: pyridine

With pyridine; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.06.033

Reference yield:

: 351-83-7
4'-fluoroacetanilide

: 227951-71-5
(2R)-2-{[N,N-di(4-fluorophenyl)-carbamoyloxy]methyl}-5-[(ethoxycarbonyl)methoxy]-2-hydroxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: Multi-step reaction with 4 steps

1: CuCl; K₂CO₃ / xylene

2: aq. NaOH / ethanol

3: pyridine / CH₂Cl₂

4: pyridine

With pyridine; sodium hydroxide; potassium carbonate; copper(l) chloride; In ethanol; dichloromethane; xylene;
DOI:10.1016/j.bmcl.2006.06.033