Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

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Chemical Name:Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester
CAS No.:86979-47-7
Molecular Formula:C₆₆H₅₆ClN₆O₉P
Molecular Weight:1143.63
Hs Code.:

Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

Synonyms:Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

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Chemical Property of Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

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Technology Process of Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

There total 5 articles about Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 86979-44-4
(chloro-2 trityl-4 phenyl)β-cyanoethyl phosphate de triethylammonium

: 64325-78-6
N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

: 86979-47-7
Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

Guidance literature:: With 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; In pyridine; for 1h; Ambient temperature;
DOI:10.1016/S0040-4039(00)88013-2

Reference yield:

: 978-86-9
4-tritylphenol

: 86979-47-7
Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: N-chloroacetamide/HCl / H₂O; dioxane

2: POCl₃,ethyl-1 methyl-2 chloro-5 imidazole

3: pyridine

4: 65 percent / pyridine / 1 h / Ambient temperature

5: 90 percent / mesitylsulfonyl-1 nitro-3 triazole-1,2,4 / pyridine / 1 h / Ambient temperature

With pyridine; hydrogenchloride; N-chloroacetamide; POCl₃,ethyl-1 methyl-2 chloro-5 imidazole; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; trichlorophosphate; In 1,4-dioxane; pyridine; water;
DOI:10.1016/S0040-4039(00)88013-2

Reference yield:

: 859820-69-2
2-chloro-4-trityl-phenol

: 86979-47-7
Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: POCl₃,ethyl-1 methyl-2 chloro-5 imidazole

2: pyridine

3: 65 percent / pyridine / 1 h / Ambient temperature

4: 90 percent / mesitylsulfonyl-1 nitro-3 triazole-1,2,4 / pyridine / 1 h / Ambient temperature

With pyridine; POCl₃,ethyl-1 methyl-2 chloro-5 imidazole; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; trichlorophosphate; In pyridine;
DOI:10.1016/S0040-4039(00)88013-2