methyl 1-(4-chlorophenyl)-4-phenylisoquinoline-3-carboxylate

Base Information

• Chemical Name: methyl 1-(4-chlorophenyl)-4-phenylisoquinoline-3-carboxylate
• CAS No.: 1610565-58-6
• Molecular Formula: C₂₃H₁₆ClNO₂
• Molecular Weight: 373.839
• Mol file: 1610565-58-6.mol

Synonyms:methyl 1-(4-chlorophenyl)-4-phenylisoquinoline-3-carboxylate

Chemical Property of methyl 1-(4-chlorophenyl)-4-phenylisoquinoline-3-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of methyl 1-(4-chlorophenyl)-4-phenylisoquinoline-3-carboxylate

There total 5 articles about methyl 1-(4-chlorophenyl)-4-phenylisoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-Chlorophenylboronic acid (1679-18-1) + methyl 2-isocyano-3,3-diphenyl acrylate (76203-05-9) → methyl 1-(4-chlorophenyl)-4-phenylisoquinoline-3-carboxylate (1610565-58-6)

Guidance literature:

With oxygen; manganese(II) acetylacetonate dihydrate; In toluene; at 80 ℃; for 2h; Schlenk technique;

DOI:10.1039/c4cc06427e

Reference yield: 87.0%

bis(4-chlorophenyl)iodonium tetrafluoroborate + methyl 2-isocyano-3,3-diphenyl acrylate (76203-05-9) → methyl 1-(4-chlorophenyl)-4-phenylisoquinoline-3-carboxylate (1610565-58-6)

Guidance literature:

With tris[2-phenylpyridinato-C²,N]iridium(III); sodium carbonate; In methanol; at 26 ℃; for 24h; Inert atmosphere; Irradiation;

DOI:10.1039/c4cc01122h

Reference yield: 81.0%

methyl 2-isocyano-3,3-diphenyl acrylate (76203-05-9) + N-4-chlorophenylhydrazine (1073-69-4) → methyl 1-(4-chlorophenyl)-4-phenylisoquinoline-3-carboxylate (1610565-58-6)

Guidance literature:

With tert-Butyl peroxybenzoate; manganese(II) acetate; In acetonitrile; at 60 ℃;

upstream raw materials:

methyl 2-isocyano-3,3-diphenyl acrylate

benzophenone

2-Formylamino-3,3-diphenyl-acrylic acid methyl ester

4-Chlorophenylboronic acid