5-benzyloxy-3-hydroxy-2-methyl-pentanoic acid 1-(toluene-4-sulfonylamino)-indan-2-yl ester

Base Information

Chemical Name:5-benzyloxy-3-hydroxy-2-methyl-pentanoic acid 1-(toluene-4-sulfonylamino)-indan-2-yl ester
CAS No.:503620-03-9
Molecular Formula:C₂₉H₃₃NO₆S
Molecular Weight:523.65
Hs Code.:

Synonyms:5-benzyloxy-3-hydroxy-2-methyl-pentanoic acid 1-(toluene-4-sulfonylamino)-indan-2-yl ester

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Chemical Property of 5-benzyloxy-3-hydroxy-2-methyl-pentanoic acid 1-(toluene-4-sulfonylamino)-indan-2-yl ester

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Technology Process of 5-benzyloxy-3-hydroxy-2-methyl-pentanoic acid 1-(toluene-4-sulfonylamino)-indan-2-yl ester

There total 1 articles about 5-benzyloxy-3-hydroxy-2-methyl-pentanoic acid 1-(toluene-4-sulfonylamino)-indan-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 19790-60-4
3-Benzyloxypropanal

: 175441-30-2
(1R,2S)-1-(N-tosylamino)-2-indanyl propionate

: 503620-03-9
5-benzyloxy-3-hydroxy-2-methyl-pentanoic acid 1-(toluene-4-sulfonylamino)-indan-2-yl ester

Guidance literature:: 3-Benzyloxypropanal; (1R,2S)-1-(N-tosylamino)-2-indanyl propionate; With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 23 ℃;

3-Benzyloxypropanal; With titanium tetrachloride; In dichloromethane; at -78 ℃; for 2h; Further stages.;
DOI:10.1021/ja021385j

Reference yield: 91.0%

: 503620-03-9
5-benzyloxy-3-hydroxy-2-methyl-pentanoic acid 1-(toluene-4-sulfonylamino)-indan-2-yl ester

: 503620-04-0
(2S,3S)-5-(benzyloxy)-2-methylpentane-1,3-diol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 23 ℃;
DOI:10.1021/ja021385j

Reference yield:

: 503620-03-9
5-benzyloxy-3-hydroxy-2-methyl-pentanoic acid 1-(toluene-4-sulfonylamino)-indan-2-yl ester

: 503620-06-2
{2-[5-(2-benzyloxy-ethyl)-4-methyl-tetrahydro-furan-2-yloxy]-ethyl}-trimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / LAH / tetrahydrofuran / 0 - 23 °C

2: 86 percent / PhLi / tetrahydrofuran / -78 - 23 °C

3: 95 percent / dimethylsulfoxide / 80 °C

4: 98 percent / HCl / methanol; H₂O / 48 h / 70 °C

5: DIBAL-H / toluene / 3 h / -78 °C

6: p-TsOH; MgSO₄ / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; diisobutylaluminium hydride; magnesium sulfate; toluene-4-sulfonic acid; phenyllithium; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1021/ja021385j