(3aR,4S,6aS)-6a-(2-fluorophenyl)-4-(trifluoromethyl)hexahydrofuro[3,4-c]isoxazole

Base Information

Chemical Name:(3aR,4S,6aS)-6a-(2-fluorophenyl)-4-(trifluoromethyl)hexahydrofuro[3,4-c]isoxazole
CAS No.:1262799-41-6
Molecular Formula:C₁₂H₁₁F₄NO₂
Molecular Weight:277.218
Hs Code.:

Synonyms:(3aR,4S,6aS)-6a-(2-fluorophenyl)-4-(trifluoromethyl)hexahydrofuro[3,4-c]isoxazole

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Chemical Property of (3aR,4S,6aS)-6a-(2-fluorophenyl)-4-(trifluoromethyl)hexahydrofuro[3,4-c]isoxazole

Chemical Property:

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Technology Process of (3aR,4S,6aS)-6a-(2-fluorophenyl)-4-(trifluoromethyl)hexahydrofuro[3,4-c]isoxazole

There total 15 articles about (3aR,4S,6aS)-6a-(2-fluorophenyl)-4-(trifluoromethyl)hexahydrofuro[3,4-c]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: C₁₄H₁₃F₄NO₃

: 1262799-41-6
(3aR,4S,6aS)-6a-(2-fluorophenyl)-4-(trifluoromethyl)hexahydrofuro[3,4-c]isoxazole

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 100 ℃; for 3h;

Reference yield:

: 1262799-40-5
(S)-1-(2-fluorophenyl)-2-((1,1,1-trifluorobut-3-en-2-yl)oxy)ethanone oxime

: 1262799-41-6
(3aR,4S,6aS)-6a-(2-fluorophenyl)-4-(trifluoromethyl)hexahydrofuro[3,4-c]isoxazole

Guidance literature:: With hydroquinone; In xylenes; at 140 ℃; for 22h;

Reference yield:

: 1262799-37-0
tert-butyl {[(2S)-1,1,1-trifluorobut-3-en-2-yl]oxy}acetate

: 1262799-41-6
(3aR,4S,6aS)-6a-(2-fluorophenyl)-4-(trifluoromethyl)hexahydrofuro[3,4-c]isoxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: formic acid / 20 °C / Ice-cooling

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 1.08 h / Ice-cooling

2.2: 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 1.42 h / -78 - -60 °C / Inert atmosphere

3.2: 2 h / -60 °C

4.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.33 h / 50 °C

5.1: hydroquinone / xylenes / 22 h / 140 °C

With n-butyllithium; formic acid; hydroxylamine hydrochloride; sodium acetate; hydroquinone; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; hexane; dichloromethane; xylenes;