(R)-4-Benzyloxycarbonylamino-2-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-butyric acid

Base Information

Chemical Name:(R)-4-Benzyloxycarbonylamino-2-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-butyric acid
CAS No.:849773-58-6
Molecular Formula:C₂₇H₃₀N₂O₇S
Molecular Weight:526.61
Hs Code.:

Synonyms:(R)-4-Benzyloxycarbonylamino-2-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-butyric acid

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Chemical Property of (R)-4-Benzyloxycarbonylamino-2-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-butyric acid

Chemical Property:

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Technology Process of (R)-4-Benzyloxycarbonylamino-2-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-butyric acid

There total 3 articles about (R)-4-Benzyloxycarbonylamino-2-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 849773-56-4
(R)-tert-butyl 8-(biphenyl-4-ylsulfonyl)-10-methyl-3-oxo-1-phenyl-2,9-dioxa-4,8-diazaundecane-7-carboxylate

: 849773-58-6
(R)-4-Benzyloxycarbonylamino-2-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-butyric acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 5h;
DOI:10.1016/j.bmcl.2005.01.024

Reference yield:

: 40371-50-4
S-4-benzyloxycarbonylamino-2-hydroxybutyric acid

: 849773-58-6
(R)-4-Benzyloxycarbonylamino-2-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 3 h / 95 °C

2: TPP; DEAD / tetrahydrofuran / 5 h / 0 °C

3: TFA / CH₂Cl₂ / 5 h / 0 °C

With thiamine diphosphate; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene; 2: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.01.024

Reference yield:

: 849773-54-2
tert-butyl (2S)-4-{[(benzyloxy)carbonyl]amino}-2-hydroxybutanoate

: 849773-58-6
(R)-4-Benzyloxycarbonylamino-2-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: TPP; DEAD / tetrahydrofuran / 5 h / 0 °C

2: TFA / CH₂Cl₂ / 5 h / 0 °C

With thiamine diphosphate; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.01.024