(4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-yl)phenylmethanol

Base Information

• Chemical Name: (4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-yl)phenylmethanol
• CAS No.: 942261-81-6
• Molecular Formula: C₂₃H₃₁ClN₂OSi
• Molecular Weight: 415.05

Synonyms:(4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-yl)phenylmethanol

Chemical Property of (4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-yl)phenylmethanol

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of (4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-yl)phenylmethanol

There total 1 articles about (4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-yl)phenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

benzaldehyde (100-52-7) + 4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine (651744-48-8) → (4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-yl)phenylmethanol (942261-81-6)

Guidance literature:

4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine; With sec.-butyllithium; In tetrahydrofuran; hexane; cyclohexane; at -78 ℃; for 0.5h;

benzaldehyde; In tetrahydrofuran; hexane; cyclohexane; at 20 ℃; for 14h;

DOI:10.1055/s-2008-1067103

Reference yield: 77.0%

(4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-yl)phenylmethanol (942261-81-6) → phenyl(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-yl)methanol (1067887-47-1)

Guidance literature:

With 5%-palladium/activated carbon; ammonium formate; In tetrahydrofuran; water; at 20 ℃; for 28h; Inert atmosphere;

DOI:10.1055/s-2008-1067103

Reference yield:

(4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-yl)phenylmethanol (942261-81-6) → [4-Chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-yl](phenyl)methanone (942261-82-7)

Guidance literature:

With manganese(IV) oxide; In toluene; for 18h; Reflux;

upstream raw materials:

benzaldehyde

4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

phenyl(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-yl)methanol

[4-Chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-yl](phenyl)methanone

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