2'-deoxy-2'-α-C-2'-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

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Chemical Name:2'-deoxy-2'-α-C-2'-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite
CAS No.:185141-94-0
Molecular Formula:C₄₁H₅₀N₅O₉P
Molecular Weight:787.85
Hs Code.:

Synonyms:2'-deoxy-2'-α-C-2'-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

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Chemical Property of 2'-deoxy-2'-α-C-2'-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

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Technology Process of 2'-deoxy-2'-α-C-2'-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

There total 12 articles about 2'-deoxy-2'-α-C-2'-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 171503-92-7
2'-deoxy-2'-α-C-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine

: 185141-94-0
2'-deoxy-2'-α-C-2'-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

Guidance literature:: With N,N-diisopropylamine tetrazolide; In acetonitrile; for 16h;
DOI:10.1016/j.tet.2006.11.024

Reference yield: 29.0%

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 171503-92-7
2-[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide

: 185141-94-0
Diisopropyl-phosphoramidous acid (2R,3S,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-carbamoylmethyl-5-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: With N,N-diisopropylamine tetrazolide; In dichloromethane; for 16h;
DOI:10.1021/jo9614607

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 185141-94-0
2'-deoxy-2'-α-C-2'-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / pyridine / CH₂Cl₂ / 4 h

2: 52 percent / diisopropylammonium tetrazolide / acetonitrile / 16 h

With pyridine; N,N-diisopropylamine tetrazolide; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2006.11.024