2'-deoxy-2'-α-C-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine

Base Information

• Chemical Name: 2'-deoxy-2'-α-C-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine
• CAS No.: 171503-92-7
• Molecular Formula: C₃₂H₃₃N₃O₈
• Molecular Weight: 587.629
• Mol file: 171503-92-7.mol

Synonyms:2'-deoxy-2'-α-C-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine

Chemical Property of 2'-deoxy-2'-α-C-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2'-deoxy-2'-α-C-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine

There total 14 articles about 2'-deoxy-2'-α-C-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5'-O-Dimethoxytrityluridine 2'-deoxy-2'-α-C,3'-O-γ-butyrolactone (171503-94-9) → 2'-deoxy-2'-α-C-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine (171503-92-7)

Guidance literature:

With ammonia; In methanol; for 8h;

Reference yield: 56.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 2-[(2R,3R,4S,5R)-4-Hydroxy-5-hydroxymethyl-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide (171503-82-5) → 2-[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide (171503-92-7)

Guidance literature:

With pyridine; In dichloromethane; for 1h;

DOI:10.1021/jo9614607

Reference yield: 45.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 2'-deoxy-2'-α-C-(amidomethyl)uridine (171503-82-5) → 2'-deoxy-2'-α-C-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine (171503-92-7)

Guidance literature:

With pyridine; In dichloromethane; for 4h;

DOI:10.1016/j.tet.2006.11.024

upstream raw materials:

4,4'-dimethoxytrityl chloride

2'-deoxy-2'-α-C-(amidomethyl)uridine

5'-O-Dimethoxytrityluridine 2'-deoxy-2'-α-C,3'-O-γ-butyrolactone

2'-deoxy-2'-α-C-(amidomethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxy)uridine

Downstream raw materials:

2'-deoxy-2'-α-C-2'-(amidomethyl)-5'-O-(4,4'-dimethoxytrityl)uridine-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

C₄₈H₄₉N₆O₁₇P

C₄₈H₅₁N₆O₁₈P

Diisopropyl-phosphoramidous acid (2R,3S,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-carbamoylmethyl-5-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester