tert-butyl 3-({4-[(tert-butoxycarbonyl)amino]-5-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl}methyl)-5-(4-chlorobenzyl)-4H-1,2,4-triazol-4-ylcarbamate

Base Information

• Chemical Name: tert-butyl 3-({4-[(tert-butoxycarbonyl)amino]-5-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl}methyl)-5-(4-chlorobenzyl)-4H-1,2,4-triazol-4-ylcarbamate
• CAS No.: 1271225-75-2
• Molecular Formula: C₂₉H₃₄Cl₂N₈O₄
• Molecular Weight: 629.546
• Mol file: 1271225-75-2.mol

Synonyms:tert-butyl 3-({4-[(tert-butoxycarbonyl)amino]-5-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl}methyl)-5-(4-chlorobenzyl)-4H-1,2,4-triazol-4-ylcarbamate

Chemical Property of tert-butyl 3-({4-[(tert-butoxycarbonyl)amino]-5-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl}methyl)-5-(4-chlorobenzyl)-4H-1,2,4-triazol-4-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 3-({4-[(tert-butoxycarbonyl)amino]-5-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl}methyl)-5-(4-chlorobenzyl)-4H-1,2,4-triazol-4-ylcarbamate

There total 3 articles about tert-butyl 3-({4-[(tert-butoxycarbonyl)amino]-5-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl}methyl)-5-(4-chlorobenzyl)-4H-1,2,4-triazol-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

malonic acid dihydrazide (3815-86-9) + tert-butyl 2-[2-(4-chlorophenyl)-1-ethoxyethylidene]hydrazinecarboxylate (159016-29-2) → tert-butyl 3-({4-[(tert-butoxycarbonyl)amino]-5-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl}methyl)-5-(4-chlorobenzyl)-4H-1,2,4-triazol-4-ylcarbamate (1271225-75-2)

Guidance literature:

at 95 ℃; for 2h;

DOI:10.3906/kim-1004-570

Reference yield:

t-butoxycarbonylhydrazine (870-46-2) → tert-butyl 3-({4-[(tert-butoxycarbonyl)amino]-5-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl}methyl)-5-(4-chlorobenzyl)-4H-1,2,4-triazol-4-ylcarbamate (1271225-75-2)

Guidance literature:

Multi-step reaction with 2 steps

2: 2 h / 95 °C

DOI:10.3906/kim-1004-570

Reference yield:

C10H13ClN2O*ClH (1271225-72-9) → tert-butyl 3-({4-[(tert-butoxycarbonyl)amino]-5-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl}methyl)-5-(4-chlorobenzyl)-4H-1,2,4-triazol-4-ylcarbamate (1271225-75-2)

Guidance literature:

Multi-step reaction with 2 steps

2: 2 h / 95 °C

DOI:10.3906/kim-1004-570

upstream raw materials:

malonic acid dihydrazide

tert-butyl 2-[2-(4-chlorophenyl)-1-ethoxyethylidene]hydrazinecarboxylate

C₁₀H₁₃ClN₂O*ClH

t-butoxycarbonylhydrazine

Downstream raw materials:

3-{[4-amino-5-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl]methyl}-5-(4-chlorobenzyl)-4H-1,2,4-triazol-4-amine