3-[[bis(2-hydroxyethyl)amino]methyl]-N-[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]benzamide

Base Information

Chemical Name:3-[[bis(2-hydroxyethyl)amino]methyl]-N-[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]benzamide
CAS No.:1443255-28-4
Molecular Formula:C₃₄H₃₅ClF₃N₅O₄
Molecular Weight:670.131
Hs Code.:

Synonyms:3-[[bis(2-hydroxyethyl)amino]methyl]-N-[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]benzamide

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Chemical Property of 3-[[bis(2-hydroxyethyl)amino]methyl]-N-[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]benzamide

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Technology Process of 3-[[bis(2-hydroxyethyl)amino]methyl]-N-[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]benzamide

There total 8 articles about 3-[[bis(2-hydroxyethyl)amino]methyl]-N-[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443255-06-8
3-(chloromethyl)-N-[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]benzamide

: 111-42-2
2,2'-iminobis[ethanol]

: 1443255-28-4
3-[[bis(2-hydroxyethyl)amino]methyl]-N-[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]benzamide

Guidance literature:: With potassium carbonate; N,N-dimethyl-formamide; at 120 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 1441141-76-9
1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole

: 1443255-28-4
3-[[bis(2-hydroxyethyl)amino]methyl]-N-[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-iodo-succinimide; acetic acid / 0.25 h / 150 °C / Microwave irradiation

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 - 0 °C

2.2: 2 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

4.1: 0.33 h / 90 °C

5.1: ammonium chloride; zinc / methanol / 2 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

7.1: potassium carbonate; N,N-dimethyl-formamide / 0.25 h / 120 °C / Microwave irradiation

With N-iodo-succinimide; isopropylmagnesium chloride; potassium carbonate; ammonium chloride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; zinc; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1441141-81-6
(5-chloro-2-nitro-phenyl)-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanol

: 1443255-28-4
3-[[bis(2-hydroxyethyl)amino]methyl]-N-[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

2: 0.33 h / 90 °C

3: ammonium chloride; zinc / methanol / 2 h / Reflux

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

5: potassium carbonate; N,N-dimethyl-formamide / 0.25 h / 120 °C / Microwave irradiation

With potassium carbonate; ammonium chloride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; zinc; In methanol; dichloromethane;