acetic acid (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]-1-phenylprop-2-enol ester

Base Information

• Chemical Name: acetic acid (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]-1-phenylprop-2-enol ester
• CAS No.: 514797-27-4
• Molecular Formula: C₂₃H₃₀O₃Si
• Molecular Weight: 382.575

Synonyms:acetic acid (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]-1-phenylprop-2-enol ester

Chemical Property of acetic acid (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]-1-phenylprop-2-enol ester

Chemical Property:

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Technology Process of acetic acid (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]-1-phenylprop-2-enol ester

There total 8 articles about acetic acid (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]-1-phenylprop-2-enol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

acetyl chloride (75-36-5) + (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]-1-phenylprop-2-enol (514797-29-6) → acetic acid (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]-1-phenylprop-2-enol ester (514797-27-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 25 ℃;

DOI:10.1081/SCC-120014986

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → acetic acid (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]-1-phenylprop-2-enol ester (514797-27-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 64 percent / imidazole / dimethylformamide / 24 h / 25 °C

2.1: Mg / diethyl ether

2.2: diethyl ether / 0 - 25 °C

3.1: 76 percent / pyridine / CH₂Cl₂ / 0 - 25 °C

With pyridine; 1H-imidazole; magnesium; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; 2.1: Grignard reaction / 2.2: Gignard reaction;

DOI:10.1081/SCC-120014986

Reference yield:

bromobenzene (108-86-1,52753-63-6) → acetic acid (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]-1-phenylprop-2-enol ester (514797-27-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Mg / diethyl ether

1.2: diethyl ether / 0 - 25 °C

2.1: 76 percent / pyridine / CH₂Cl₂ / 0 - 25 °C

With pyridine; magnesium; In diethyl ether; dichloromethane; 1.1: Grignard reaction / 1.2: Gignard reaction;

DOI:10.1081/SCC-120014986

upstream raw materials:

acetyl chloride

(E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]-1-phenylprop-2-enol

bromobenzene

(E)-3-(2-hydroxyphenyl)propenal

Downstream raw materials:

2-phenylchromene

acetic acid (E)-3-(2-hydroxyphenyl)-1-phenylprop-2-enol ester

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