(R)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridazine

Base Information

Chemical Name:(R)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridazine
CAS No.:909729-97-1
Molecular Formula:C₁₇H₂₆N₂O₂Si
Molecular Weight:318.491
Hs Code.:

Synonyms:(R)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridazine

Suppliers and Price of (R)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridazine

Chemical Property:

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Technology Process of (R)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridazine

There total 4 articles about (R)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 909729-98-2
(R)-5-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridazine

: 98-88-4
benzoyl chloride

: 909729-97-1
(R)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridazine

Guidance literature:: With pyridine; at 0 - 23 ℃;
DOI:10.1016/j.tetasy.2006.06.004

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 909729-97-1
(R)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridazine

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / imidazole / dimethylformamide / 0 - 23 °C

2: 77 percent / DIBAL-H / hexane / 2 h / -78 °C

3: 91 percent / hydrazine monohydrate / ethanol / 17 h / 0 - 23 °C

4: 98 percent / pyridine / 0 - 23 °C

With pyridine; 1H-imidazole; diisobutylaluminium hydride; hydrazine hydrate; In ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2006.06.004

Reference yield:

: 119136-98-0
(3R)-3-<(tert-butyl)dimethylsilyloxy>-4-chlorobutanal

: 909729-97-1
(R)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / hydrazine monohydrate / ethanol / 17 h / 0 - 23 °C

2: 98 percent / pyridine / 0 - 23 °C

With pyridine; hydrazine hydrate; In ethanol;
DOI:10.1016/j.tetasy.2006.06.004