5-amino-1-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-N-(2,4-dinitrophenyl)-1H-imidazole-4-carboxamide

Base Information

Chemical Name:5-amino-1-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-N-(2,4-dinitrophenyl)-1H-imidazole-4-carboxamide
CAS No.:1643356-25-5
Molecular Formula:C₃₃H₅₈N₆O₉Si₃
Molecular Weight:767.115
Hs Code.:

5-amino-1-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-N-(2,4-dinitrophenyl)-1H-imidazole-4-carboxamide

Synonyms:5-amino-1-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-N-(2,4-dinitrophenyl)-1H-imidazole-4-carboxamide

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Chemical Property of 5-amino-1-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-N-(2,4-dinitrophenyl)-1H-imidazole-4-carboxamide

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Technology Process of 5-amino-1-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-N-(2,4-dinitrophenyl)-1H-imidazole-4-carboxamide

There total 2 articles about 5-amino-1-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-N-(2,4-dinitrophenyl)-1H-imidazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 886227-18-5
2',3',5'-O-tris(tert-butyldimethylsilyl)-1-(2,4-dinitrophenyl)inosine

: 1643356-25-5
5-amino-1-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-N-(2,4-dinitrophenyl)-1H-imidazole-4-carboxamide

Guidance literature:: With ethylenediamine; In tetrahydrofuran; at 20 - 50 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c4ob00705k

Reference yield:

: 58-63-9
inosine

: 1643356-25-5
5-amino-1-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-N-(2,4-dinitrophenyl)-1H-imidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole; tert-butyldimethylsilyl chloride / N,N-dimethyl-formamide / 48 h / 20 - 60 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 - 60 °C / Inert atmosphere

3: ethylenediamine / tetrahydrofuran / 3 h / 20 - 50 °C / Inert atmosphere

With 1H-imidazole; potassium carbonate; tert-butyldimethylsilyl chloride; ethylenediamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c4ob00705k