7-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-(2,4-dinitrophenyl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one

Base Information

Chemical Name:7-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-(2,4-dinitrophenyl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one
CAS No.:1643356-27-7
Molecular Formula:C₂₇H₄₁N₇O₉Si₂
Molecular Weight:663.835
Hs Code.:

7-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-(2,4-dinitrophenyl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one

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Chemical Property of 7-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-(2,4-dinitrophenyl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one

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Technology Process of 7-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-(2,4-dinitrophenyl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one

There total 5 articles about 7-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-(2,4-dinitrophenyl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1643356-26-6
C₂₇H₄₄N₆O₉Si₂

: 1643356-27-7
7-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-(2,4-dinitrophenyl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one

Guidance literature:: With hydrogenchloride; sodium nitrite; In water; acetonitrile; at 0 ℃; for 1h;
DOI:10.1039/c4ob00705k

Reference yield:

: 58-63-9
inosine

: 1643356-27-7
7-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-(2,4-dinitrophenyl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1H-imidazole; tert-butyldimethylsilyl chloride / N,N-dimethyl-formamide / 48 h / 20 - 60 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 - 60 °C / Inert atmosphere

3: ethylenediamine / tetrahydrofuran / 3 h / 20 - 50 °C / Inert atmosphere

4: ammonium fluoride / water; N,N-dimethyl-formamide / 24 h / 20 °C

5: sodium nitrite; hydrogenchloride / water; acetonitrile / 1 h / 0 °C

With 1H-imidazole; hydrogenchloride; ammonium fluoride; potassium carbonate; tert-butyldimethylsilyl chloride; ethylenediamine; sodium nitrite; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c4ob00705k

Reference yield:

: 1643356-25-5
5-amino-1-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-N-(2,4-dinitrophenyl)-1H-imidazole-4-carboxamide

: 1643356-27-7
7-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-(2,4-dinitrophenyl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium fluoride / water; N,N-dimethyl-formamide / 24 h / 20 °C

2: sodium nitrite; hydrogenchloride / water; acetonitrile / 1 h / 0 °C

With hydrogenchloride; ammonium fluoride; sodium nitrite; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c4ob00705k