2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-amine hydrochloride

Base Information

Chemical Name:2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-amine hydrochloride
CAS No.:1258504-40-3
Molecular Formula:C₉H₁₀ClN₃*ClH
Molecular Weight:232.112
Hs Code.:

Synonyms:2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-amine hydrochloride

Suppliers and Price of 2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-amine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-amine hydrochloride

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Technology Process of 2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-amine hydrochloride

There total 7 articles about 2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1258504-38-9
2-(5-chloro-2-(triethylsilyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanamine

: 1258504-40-3
2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-amine hydrochloride

Guidance literature:: 2-(5-chloro-2-(triethylsilyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanamine; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield: 89.0%

: 1258504-39-0
N-(2-(5-chloro-2-(triethylsilyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl)-5-(2,5-difluorobenzyl)isoxazole-3-carboxamide

: 1258504-40-3
2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-amine hydrochloride

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1072-98-6
5-chloro-2-pyridylamine

: 1258504-40-3
2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-amine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: iodine; silver sulfate / ethanol / 20 °C

2: sodium carbonate; lithium chloride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 20 h / 100 °C

3: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 h

4: sodium azide / N,N-dimethyl-formamide / 18 h / 80 °C

5: triphenylphosphine / methanol / 1 h / 80 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With sodium azide; carbon tetrabromide; tetrabutyl ammonium fluoride; iodine; sodium carbonate; silver sulfate; triphenylphosphine; lithium chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;