1,3-Bis(2-hydroxy-5-methylphenyl)tetrahydro-2(1H)-pyrimidinone

Base Information

Chemical Name:1,3-Bis(2-hydroxy-5-methylphenyl)tetrahydro-2(1H)-pyrimidinone
CAS No.:84379-39-5
Molecular Formula:C₁₈H₂₀N₂O₃
Molecular Weight:312.368
Hs Code.:
European Community (EC) Number:651-443-7

Synonyms:1,3-BIS(2-HYDROXY-5-METHYLPHENYL)TETRAHYDRO-2(1H)-PYRIMIDINONE;84379-39-5;AKOS024330505;1,3-Bis(2-hydroxy-5-methylphenyl)tetrahydropyrimidin-2(1H)-one

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3-Bis(2-hydroxy-5-methylphenyl)tetrahydro-2(1H)-pyrimidinone

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:312.14739250
Heavy Atom Count:23
Complexity:395

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C(C=C1)O)N2CCCN(C2=O)C3=C(C=CC(=C3)C)O

Technology Process of 1,3-Bis(2-hydroxy-5-methylphenyl)tetrahydro-2(1H)-pyrimidinone

There total 3 articles about 1,3-Bis(2-hydroxy-5-methylphenyl)tetrahydro-2(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.4%

: 84379-38-4
1,3-bis(2-methoxy-5-methylphenyl)tetrahydro-2-pyrimidinone

: 84379-39-5
1,3-bis(2-hydroxy-5-methylphenyl)tetrahydro-2-pyrimidinone

Guidance literature:: With boron tribromide; In dichloromethane; for 24h;
DOI:10.1021/ja00335a049

Reference yield:

: 84379-37-3
1,3-bis(2-methoxy-5-methylphenyl)urea

: 84379-39-5
1,3-bis(2-hydroxy-5-methylphenyl)tetrahydro-2-pyrimidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / NaH / tetrahydrofuran

2: 77 percent / HBr / acetic acid

With hydrogen bromide; sodium hydride; In tetrahydrofuran; acetic acid;
DOI:10.1039/c39820001219

Reference yield:

: 120-71-8
Cresidine

: 84379-39-5
1,3-bis(2-hydroxy-5-methylphenyl)tetrahydro-2-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / tetrahydrofuran

2: 89 percent / NaH / tetrahydrofuran

3: 77 percent / HBr / acetic acid

With hydrogen bromide; sodium hydride; In tetrahydrofuran; acetic acid;
DOI:10.1039/c39820001219