2β,3α-Allococaine benzoyl thioester

Base Information

Chemical Name:2β,3α-Allococaine benzoyl thioester
CAS No.:212122-04-8
Molecular Formula:C₁₇H₂₁NO₃S
Molecular Weight:319.425
Hs Code.:

Synonyms:2β,3α-Allococaine benzoyl thioester

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Chemical Property of 2β,3α-Allococaine benzoyl thioester

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Technology Process of 2β,3α-Allococaine benzoyl thioester

There total 3 articles about 2β,3α-Allococaine benzoyl thioester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 98-88-4
benzoyl chloride

: (1R,2S,3R,5S)-3-(4-Methoxy-benzylsulfanyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

: 212122-04-8
2β,3α-Allococaine benzoyl thioester

Guidance literature:: (1R,2S,3R,5S)-3-(4-Methoxy-benzylsulfanyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester; With mercury(II) diacetate; In trifluoroacetic acid; at 0 ℃; for 0.5h;

benzoyl chloride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/tx9800203

Reference yield:

: 6258-60-2
p-methoxybenzylmercaptan

: 212122-04-8
2β,3α-Allococaine benzoyl thioester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 40 percent / Diisopropylethylamine / methanol / 48 h

2.1: Hg(OAc)2 / trifluoroacetic acid / 0.5 h / 0 °C

2.2: 32 percent / Triethylamine / tetrahydrofuran / 2 h / 20 °C

With mercury(II) diacetate; N-ethyl-N,N-diisopropylamine; In methanol; trifluoroacetic acid; 1.1: Addition / 2.1: Debenzylation / 2.2: Benzoylation;
DOI:10.1021/tx9800203

Reference yield:

: 50373-10-9
methyl ecgonidine

: 212122-04-8
2β,3α-Allococaine benzoyl thioester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 40 percent / Diisopropylethylamine / methanol / 48 h

2.1: Hg(OAc)2 / trifluoroacetic acid / 0.5 h / 0 °C

2.2: 32 percent / Triethylamine / tetrahydrofuran / 2 h / 20 °C

With mercury(II) diacetate; N-ethyl-N,N-diisopropylamine; In methanol; trifluoroacetic acid; 1.1: Addition / 2.1: Debenzylation / 2.2: Benzoylation;
DOI:10.1021/tx9800203