3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

Base Information

Chemical Name:3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide
CAS No.:847976-36-7
Molecular Formula:C₂₆H₂₀N₄O₂S₂
Molecular Weight:484.602
Hs Code.:

Synonyms:3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

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Chemical Property of 3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

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Technology Process of 3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

There total 7 articles about 3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 847976-33-4
(3-Cyano-4-phenyl-6-thiophen-2-yl-pyridin-2-ylsulfanyl)-acetic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

: 847976-36-7
3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

Guidance literature:: With sodium ethanolate; In ethanol; for 0.25h; Heating;
DOI:10.1080/10426500490467147

Reference yield:

: 3988-77-0,39078-33-6,69656-36-6
3-phenyl-1-thiophen-2-yl-propenone

: 847976-36-7
3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

Guidance literature:: Multi-step reaction with 5 steps

1: 43 percent / piperidine / ethanol / 4 h / Heating

2: 95 percent / sodium acetate trihydrate / ethanol / 2 h / Heating

3: 86 percent / N₂H₄*H₂O / ethanol / 4 h / Heating

4: 98 percent / ethanol / 4 h / Heating

5: 98 percent / NaOEt / ethanol / 0.25 h / Heating

With piperidine; sodium ethanolate; sodium acetate; hydrazine hydrate; In ethanol; 5: Thorpe-Ziegler cyclization;
DOI:10.1080/10426500490467147

Reference yield:

: 82127-11-5
4-phenyl-6-(thiophen-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile

: 847976-36-7
3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / sodium acetate trihydrate / ethanol / 2 h / Heating

2: 86 percent / N₂H₄*H₂O / ethanol / 4 h / Heating

3: 98 percent / ethanol / 4 h / Heating

4: 98 percent / NaOEt / ethanol / 0.25 h / Heating

With sodium ethanolate; sodium acetate; hydrazine hydrate; In ethanol; 4: Thorpe-Ziegler cyclization;
DOI:10.1080/10426500490467147