1-[{[(4S,5S)-5-(benzyloxymethyl)2,2-dimethyl-1,3-dioxolan-4-yl]methyl}(fluoren-9-ylmethoxycarbonyl)amino]-3-(tert-butyldimethylsilyloxy)propan-2-one

Base Information

Chemical Name:1-[{[(4S,5S)-5-(benzyloxymethyl)2,2-dimethyl-1,3-dioxolan-4-yl]methyl}(fluoren-9-ylmethoxycarbonyl)amino]-3-(tert-butyldimethylsilyloxy)propan-2-one
CAS No.:871702-75-9
Molecular Formula:C₃₈H₄₉NO₇Si
Molecular Weight:659.895
Hs Code.:

1-[{[(4S,5S)-5-(benzyloxymethyl)2,2-dimethyl-1,3-dioxolan-4-yl]methyl}(fluoren-9-ylmethoxycarbonyl)amino]-3-(tert-butyldimethylsilyloxy)propan-2-one

Synonyms:1-[{[(4S,5S)-5-(benzyloxymethyl)2,2-dimethyl-1,3-dioxolan-4-yl]methyl}(fluoren-9-ylmethoxycarbonyl)amino]-3-(tert-butyldimethylsilyloxy)propan-2-one

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Chemical Property of 1-[{[(4S,5S)-5-(benzyloxymethyl)2,2-dimethyl-1,3-dioxolan-4-yl]methyl}(fluoren-9-ylmethoxycarbonyl)amino]-3-(tert-butyldimethylsilyloxy)propan-2-one

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Technology Process of 1-[{[(4S,5S)-5-(benzyloxymethyl)2,2-dimethyl-1,3-dioxolan-4-yl]methyl}(fluoren-9-ylmethoxycarbonyl)amino]-3-(tert-butyldimethylsilyloxy)propan-2-one

There total 5 articles about 1-[{[(4S,5S)-5-(benzyloxymethyl)2,2-dimethyl-1,3-dioxolan-4-yl]methyl}(fluoren-9-ylmethoxycarbonyl)amino]-3-(tert-butyldimethylsilyloxy)propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 871702-73-7
1-[{[(4S,5S)-5-(benzyloxymethyl)2,2-dimethyl-1,3-dioxolan-4-yl]methyl}(fluoren-9-ylmethoxycarbonyl)amino]-3-(tert-butyldimethylsilyloxy)propan-2-ol

: 871702-75-9
1-[{[(4S,5S)-5-(benzyloxymethyl)2,2-dimethyl-1,3-dioxolan-4-yl]methyl}(fluoren-9-ylmethoxycarbonyl)amino]-3-(tert-butyldimethylsilyloxy)propan-2-one

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -60 - 20 ℃; for 2.16667h;
DOI:10.1002/ejoc.200500386

Reference yield:

: 871702-70-4
benzyl{[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxalan-4-yl]methyl}amine

: 871702-75-9
1-[{[(4S,5S)-5-(benzyloxymethyl)2,2-dimethyl-1,3-dioxolan-4-yl]methyl}(fluoren-9-ylmethoxycarbonyl)amino]-3-(tert-butyldimethylsilyloxy)propan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / H₂ / Pd(OH)2/C / ethanol / 20 °C

2: 96 percent / LiNTf₂ / CH₂Cl₂ / 12 h / 20 °C

3: 78 percent / Na₂CO₃*H₂O / dioxane; H₂O / 20 °C

4: 50 percent / (COCl)2; DMSO; DIPEA / CH₂Cl₂ / 2.17 h / -60 - 20 °C

With oxalyl dichloride; hydrogen; sodium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; bis(trifluoromethane)sulfonimide lithium; palladium dihydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; 4: Swern reaction;
DOI:10.1002/ejoc.200500386

Reference yield:

: 81028-12-8
(4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-5-carboxaldehyde

: 871702-75-9
1-[{[(4S,5S)-5-(benzyloxymethyl)2,2-dimethyl-1,3-dioxolan-4-yl]methyl}(fluoren-9-ylmethoxycarbonyl)amino]-3-(tert-butyldimethylsilyloxy)propan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / NaBH(OAc)3 / tetrahydrofuran / 16 h / 20 °C

2: 99 percent / H₂ / Pd(OH)2/C / ethanol / 20 °C

3: 96 percent / LiNTf₂ / CH₂Cl₂ / 12 h / 20 °C

4: 78 percent / Na₂CO₃*H₂O / dioxane; H₂O / 20 °C

5: 50 percent / (COCl)2; DMSO; DIPEA / CH₂Cl₂ / 2.17 h / -60 - 20 °C

With oxalyl dichloride; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; bis(trifluoromethane)sulfonimide lithium; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 5: Swern reaction;
DOI:10.1002/ejoc.200500386