1-({[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}amino)-3-(tert-butyldimethylsilyloxy)propan-2-ol

Base Information

Chemical Name:1-({[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}amino)-3-(tert-butyldimethylsilyloxy)propan-2-ol
CAS No.:871702-71-5
Molecular Formula:C₂₃H₄₁NO₅Si
Molecular Weight:439.668
Hs Code.:

Synonyms:1-({[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}amino)-3-(tert-butyldimethylsilyloxy)propan-2-ol

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Chemical Property of 1-({[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}amino)-3-(tert-butyldimethylsilyloxy)propan-2-ol

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Technology Process of 1-({[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}amino)-3-(tert-butyldimethylsilyloxy)propan-2-ol

There total 2 articles about 1-({[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}amino)-3-(tert-butyldimethylsilyloxy)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 871702-67-9
{[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxalan-4-yl]methyl}amine

: 114413-26-2,123237-62-7,124150-87-4,78906-15-7
tert-butyldimethylsilyl glycidyl ether

: 871702-71-5
1-({[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}amino)-3-(tert-butyldimethylsilyloxy)propan-2-ol

Guidance literature:: With bis(trifluoromethane)sulfonimide lithium; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1002/ejoc.200500386

Reference yield:

: 871702-70-4
benzyl{[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxalan-4-yl]methyl}amine

: 871702-71-5
1-({[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}amino)-3-(tert-butyldimethylsilyloxy)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / Pd(OH)2/C / ethanol / 20 °C

2: 96 percent / LiNTf₂ / CH₂Cl₂ / 12 h / 20 °C

With hydrogen; bis(trifluoromethane)sulfonimide lithium; palladium dihydroxide; In ethanol; dichloromethane;
DOI:10.1002/ejoc.200500386