benzyl{[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxalan-4-yl]methyl}amine

Base Information

Chemical Name:benzyl{[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxalan-4-yl]methyl}amine
CAS No.:871702-70-4
Molecular Formula:C₂₁H₂₇NO₃
Molecular Weight:341.45
Hs Code.:

Synonyms:benzyl{[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxalan-4-yl]methyl}amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl{[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxalan-4-yl]methyl}amine

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Technology Process of benzyl{[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxalan-4-yl]methyl}amine

There total 1 articles about benzyl{[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxalan-4-yl]methyl}amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 81028-12-8
(4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-5-carboxaldehyde

: 100-46-9
benzylamine

: 871702-70-4
benzyl{[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxalan-4-yl]methyl}amine

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1002/ejoc.200500386

Reference yield: 99.0%

: 871702-70-4
benzyl{[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxalan-4-yl]methyl}amine

: 871702-67-9
{[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxalan-4-yl]methyl}amine

Guidance literature:: With hydrogen; palladium dihydroxide; In ethanol; at 20 ℃;
DOI:10.1002/ejoc.200500386

Reference yield:

: 871702-70-4
benzyl{[(4S,5S)-5-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxalan-4-yl]methyl}amine

: (1S,5R,7S)-7-exo-(benzyloxymethyl)-3-(fluoren-9-ylmethoxycarbonyl)-6,8-dioxa-3-azabicyclo[3.2.1]octane-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / H₂ / Pd(OH)2/C / ethanol / 20 °C

2: 96 percent / LiNTf₂ / CH₂Cl₂ / 12 h / 20 °C

3: 78 percent / Na₂CO₃*H₂O / dioxane; H₂O / 20 °C

4: 50 percent / (COCl)2; DMSO; DIPEA / CH₂Cl₂ / 2.17 h / -60 - 20 °C

5: 37 percent / TFA; MeOH / 20 °C

6: 70 percent / CrO₃; H₂SO₄ / acetone / 20 °C

With chromium(VI) oxide; methanol; oxalyl dichloride; sulfuric acid; hydrogen; sodium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; bis(trifluoromethane)sulfonimide lithium; trifluoroacetic acid; palladium dihydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; acetone; 4: Swern reaction;
DOI:10.1002/ejoc.200500386