1-(2,4-dihydroxy-5-isopropylphenyl)-5-(4-morpholin-4-ylmethylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Base Information

Chemical Name:1-(2,4-dihydroxy-5-isopropylphenyl)-5-(4-morpholin-4-ylmethylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide
CAS No.:1383717-28-9
Molecular Formula:C₂₅H₃₁N₅O₄
Molecular Weight:465.552
Hs Code.:

Synonyms:1-(2,4-dihydroxy-5-isopropylphenyl)-5-(4-morpholin-4-ylmethylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

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Chemical Property of 1-(2,4-dihydroxy-5-isopropylphenyl)-5-(4-morpholin-4-ylmethylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

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Technology Process of 1-(2,4-dihydroxy-5-isopropylphenyl)-5-(4-morpholin-4-ylmethylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

There total 14 articles about 1-(2,4-dihydroxy-5-isopropylphenyl)-5-(4-morpholin-4-ylmethylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1383718-25-9
1-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-5-(4-morpholin-4-ylmethyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

: 1383717-28-9
1-(2,4-dihydroxy-5-isopropylphenyl)-5-(4-morpholin-4-ylmethylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Guidance literature:: With hydrogen; 10 wt% Pd(OH)2 on carbon; In ethanol; for 1h; under 760.051 Torr;

Reference yield:

: 1383717-81-4
1,5-bis-benzyloxy-2-isopropyl-4-azido-benzene

: 1383717-28-9
1-(2,4-dihydroxy-5-isopropylphenyl)-5-(4-morpholin-4-ylmethylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Guidance literature:: Multi-step reaction with 6 steps

1: chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3: triethylamine / dichloromethane / 12.5 h / 0 - 20 °C

4: triethylamine / 12 h / 20 °C

5: methanol / 24 h / 80 °C / sealed tube

6: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 1 h / 760.05 Torr

With tetrabutyl ammonium fluoride; hydrogen; triethylamine; chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1093190-17-0
tert-butyl[(4-ethynylphenyl)methoxy]dimethylsilane

: 1383717-28-9
1-(2,4-dihydroxy-5-isopropylphenyl)-5-(4-morpholin-4-ylmethylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 1 h / -78 - -40 °C

1.2: -40 - 20 °C

2.1: chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4.1: triethylamine / dichloromethane / 12.5 h / 0 - 20 °C

5.1: triethylamine / 12 h / 20 °C

6.1: methanol / 24 h / 80 °C / sealed tube

7.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 1 h / 760.05 Torr

With tetrabutyl ammonium fluoride; hydrogen; triethylamine; lithium hexamethyldisilazane; chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;