1-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-5-(4-methanesulfonyloxy-methyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

Base Information

Chemical Name:1-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-5-(4-methanesulfonyloxy-methyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester
CAS No.:1383717-90-5
Molecular Formula:C₃₅H₃₅N₃O₇S
Molecular Weight:641.745
Hs Code.:

Synonyms:1-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-5-(4-methanesulfonyloxy-methyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

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Chemical Property of 1-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-5-(4-methanesulfonyloxy-methyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

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Technology Process of 1-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-5-(4-methanesulfonyloxy-methyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

There total 14 articles about 1-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-5-(4-methanesulfonyloxy-methyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383717-89-2
methyl 1-[2,4-bis(benzyloxy)cumenyl]-5-[p-(hydroxymethyl)-phenyl]-1H-1,2,3-triazole-4-carboxylate

: 124-63-0
methanesulfonyl chloride

: 1383717-90-5
1-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-5-(4-methanesulfonyloxy-methyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12.5h;

Reference yield:

: 1093190-17-0
tert-butyl[(4-ethynylphenyl)methoxy]dimethylsilane

: 1383717-90-5
1-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-5-(4-methanesulfonyloxy-methyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 1 h / -78 - -40 °C

1.2: -40 - 20 °C

2.1: chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4.1: triethylamine / dichloromethane / 12.5 h / 0 - 20 °C

With tetrabutyl ammonium fluoride; triethylamine; lithium hexamethyldisilazane; chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1155371-80-4
(((4-isopropyl-1,3-phenylene)bis(oxy))bis(methylene))dibenzene

: 1383717-90-5
1-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-5-(4-methanesulfonyloxy-methyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: nitric acid; acetic acid / 0.67 h / 70 - 80 °C

2.1: hydrogenchloride; tin(ll) chloride / ethanol; water / 4 h / 80 °C

2.2: 0 °C

3.1: trimethylsilylazide; tert.-butylnitrite / acetonitrile / 13 h / 0 - 20 °C

4.1: chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

6.1: triethylamine / dichloromethane / 12.5 h / 0 - 20 °C

With hydrogenchloride; tert.-butylnitrite; trimethylsilylazide; tetrabutyl ammonium fluoride; nitric acid; acetic acid; triethylamine; tin(ll) chloride; chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;