1-[(3R,3aR,5aS,6R,7R,9aS,9bS)-6-((R)-2-Benzyloxy-3-isopropenyl-4-methyl-pent-3-enyl)-3-((R)-1,5-dimethyl-hexyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-7-yl]-propenone

Base Information

• Chemical Name: 1-[(3R,3aR,5aS,6R,7R,9aS,9bS)-6-((R)-2-Benzyloxy-3-isopropenyl-4-methyl-pent-3-enyl)-3-((R)-1,5-dimethyl-hexyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-7-yl]-propenone
• CAS No.: 163079-83-2
• Molecular Formula: C₄₂H₆₄O₂
• Molecular Weight: 600.969
• Mol file: 163079-83-2.mol

Synonyms:1-[(3R,3aR,5aS,6R,7R,9aS,9bS)-6-((R)-2-Benzyloxy-3-isopropenyl-4-methyl-pent-3-enyl)-3-((R)-1,5-dimethyl-hexyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-7-yl]-propenone

Chemical Property of 1-[(3R,3aR,5aS,6R,7R,9aS,9bS)-6-((R)-2-Benzyloxy-3-isopropenyl-4-methyl-pent-3-enyl)-3-((R)-1,5-dimethyl-hexyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-7-yl]-propenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(3R,3aR,5aS,6R,7R,9aS,9bS)-6-((R)-2-Benzyloxy-3-isopropenyl-4-methyl-pent-3-enyl)-3-((R)-1,5-dimethyl-hexyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-7-yl]-propenone

There total 1 articles about 1-[(3R,3aR,5aS,6R,7R,9aS,9bS)-6-((R)-2-Benzyloxy-3-isopropenyl-4-methyl-pent-3-enyl)-3-((R)-1,5-dimethyl-hexyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-7-yl]-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) + (R)-1-[(3R,3aR,5aS,6R,7R,9aS,9bS)-7-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-allyl]-3-((R)-1,5-dimethyl-hexyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-6-yl]-3-isopropenyl-4-methyl-pent-3-en-2-ol (163079-81-0) → 1-[(3R,3aR,5aS,6R,7R,9aS,9bS)-6-((R)-2-Benzyloxy-3-isopropenyl-4-methyl-pent-3-enyl)-3-((R)-1,5-dimethyl-hexyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-7-yl]-propenone (163079-83-2)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/0040-4039(94)00020-Y

Reference yield: 44.0%

1-[(3R,3aR,5aS,6R,7R,9aS,9bS)-6-((R)-2-Benzyloxy-3-isopropenyl-4-methyl-pent-3-enyl)-3-((R)-1,5-dimethyl-hexyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-7-yl]-propenone (163079-83-2) → (2S,4S,5R,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-2-(1-isopropenyl-2-methyl-propenyl)-10,13-dimethyl-4-vinyl-hexadecahydro-3-oxa-cyclopenta[a]phenanthren-4-ol + 3-Benzyloxy-1-[(3R,3aR,5aS,6R,7R,9aS,9bS)-3-((R)-1,5-dimethyl-hexyl)-6-((E)-3-isopropenyl-4-methyl-penta-1,3-dienyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-7-yl]-propan-1-one

Guidance literature:

boron trifluoride diethyl etherate; In toluene; for 39h; -40 degC -> 0 degC;

DOI:10.1016/0040-4039(94)00020-Y

Reference yield:

1-[(3R,3aR,5aS,6R,7R,9aS,9bS)-6-((R)-2-Benzyloxy-3-isopropenyl-4-methyl-pent-3-enyl)-3-((R)-1,5-dimethyl-hexyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-7-yl]-propenone (163079-83-2) → benzaldehyde (100-52-7) + C35H58O + C35H58O

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given; 1.) toluene, 195 degC; 2.) hetero intramolecular Diels-Alder reaction;

DOI:10.1016/0040-4039(94)00020-Y

upstream raw materials:

benzyl bromide

(R)-1-[(3R,3aR,5aS,6R,7R,9aS,9bS)-7-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-allyl]-3-((R)-1,5-dimethyl-hexyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-6-yl]-3-isopropenyl-4-methyl-pent-3-en-2-ol

Downstream raw materials:

benzaldehyde