S,S-N₂C₁₂H₆(C₆H₄(OC₂H₄)2OCH(CH₃)CH₂)2PO(C₆H₅)

Base Information

• Chemical Name: S,S-N₂C₁₂H₆(C₆H₄(OC₂H₄)2OCH(CH₃)CH₂)2PO(C₆H₅)
• CAS No.: 888503-65-9
• Molecular Formula: C₄₄H₄₇N₂O₇P
• Molecular Weight: 746.84
• Mol file: 888503-65-9.mol

Synonyms:S,S-N₂C₁₂H₆(C₆H₄(OC₂H₄)2OCH(CH₃)CH₂)2PO(C₆H₅)

Chemical Property of S,S-N₂C₁₂H₆(C₆H₄(OC₂H₄)2OCH(CH₃)CH₂)2PO(C₆H₅)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S,S-N₂C₁₂H₆(C₆H₄(OC₂H₄)2OCH(CH₃)CH₂)2PO(C₆H₅)

There total 2 articles about S,S-N₂C₁₂H₆(C₆H₄(OC₂H₄)2OCH(CH₃)CH₂)2PO(C₆H₅) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

(S,S)-bis(2-(2-(2-iodoethoxy)ethoxy)propyl)phenylphosphine oxide + 2,9-bis(4-hydroxyphenyl)-1,10-phenanthroline (88498-43-5) → S,S-N2C12H6(C6H4(OC2H4)2OCH(CH3)CH2)2PO(C6H5) (888503-65-9)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 50 - 60 ℃; for 40h;

DOI:10.1002/anie.200503625

Reference yield:

(S,S)-bis{2-[2-(2-chloroethoxy)ethoxy]propyl}(phenyl)phosphane oxide (876609-98-2) → S,S-N2C12H6(C6H4(OC2H4)2OCH(CH3)CH2)2PO(C6H5) (888503-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / NaI / butan-2-one / 60 h / Heating

2: 35 percent / Cs₂CO₃ / dimethylformamide / 40 h / 50 - 60 °C

With caesium carbonate; sodium iodide; In N,N-dimethyl-formamide; butanone;

DOI:10.1002/anie.200503625

Reference yield: 29.0%

(S,S)-bis(2-(2-(2-iodoethoxy)ethoxy)propyl)phenylphosphine oxide + S,S-N2C12H6(C6H4(OC2H4)2OCH(CH3)CH2)2PO(C6H5) (888503-65-9) + tetrakis(actonitrile)copper(I) hexafluorophosphate (64443-05-6) + 2,9-bis(4-hydroxyphenyl)-1,10-phenanthroline (88498-43-5) → [(N2C12H6(C6H4(OC2H4)2OCH(CH3)CH2)2PO(C6H5))2(copper(I))](hexaflourophosphate)

Guidance literature:

With caesium carbonate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; (Cu(CH3CN)4)PF6 soln. (MeCN) added to N2C12H6(C6H4O3C7H14)2P(C6H5)O (CH2Cl2), stirred 0.5 h, N2C12H6(C6H4OH)2 soln. (DMF) added, stirred 1 h, (IC7H14O2)2P(C6H5)O soln. (DMF), mixt. added to Cs2CO3 suspn. within 8 h at 55-60°C, heated for 50 h; DMF removed in vac., residue dissolved in H2O/CH2Cl2, organic layer washed (brine/H2O), concd., stirred overnight with satd. soln. of KPF6, washed (brine/H2O), dried (MgSO4), evapd. to dryness, filtered through silica gel column (CH2Cl2/MeOH gradient);

DOI:10.1002/anie.200503625

upstream raw materials:

2,9-bis(4-hydroxyphenyl)-1,10-phenanthroline

(S,S)-bis{2-[2-(2-chloroethoxy)ethoxy]propyl}(phenyl)phosphane oxide