Dibenzyl-[(1S,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(2-methoxy-ethoxymethoxy)-butyl]-amine

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Chemical Name:Dibenzyl-[(1S,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(2-methoxy-ethoxymethoxy)-butyl]-amine
CAS No.:208184-48-9
Molecular Formula:C₂₉H₄₇NO₄Si
Molecular Weight:501.782
Hs Code.:

Synonyms:Dibenzyl-[(1S,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(2-methoxy-ethoxymethoxy)-butyl]-amine

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Chemical Property of Dibenzyl-[(1S,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(2-methoxy-ethoxymethoxy)-butyl]-amine

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Technology Process of Dibenzyl-[(1S,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(2-methoxy-ethoxymethoxy)-butyl]-amine

There total 6 articles about Dibenzyl-[(1S,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(2-methoxy-ethoxymethoxy)-butyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 3970-21-6
2-Methoxyethoxymethyl chloride

: 208184-47-8
(2S,3S)-1-(tert-Butyl-dimethyl-silanyloxy)-2-dibenzylamino-pentan-3-ol

: 208184-48-9
Dibenzyl-[(1S,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(2-methoxy-ethoxymethoxy)-butyl]-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 48h; Ambient temperature;
DOI:10.1016/S0040-4020(98)00232-4

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 208184-48-9
Dibenzyl-[(1S,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(2-methoxy-ethoxymethoxy)-butyl]-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / imidazole / dimethylformamide / Ambient temperature

2: 84 percent / NaBH₄, LiCl / tetrahydrofuran; ethanol / Ambient temperature

3: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) from -78 deg C to room temperature, 45 min.

4: diethyl ether / 1 h / 0 °C

5: 93 percent / diisopropylethylamine / CH₂Cl₂ / 48 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(98)00232-4

Reference yield:

: 125654-82-2
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-dibenzylamino-propionaldehyde

: 208184-48-9
Dibenzyl-[(1S,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(2-methoxy-ethoxymethoxy)-butyl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 1 h / 0 °C

2: 93 percent / diisopropylethylamine / CH₂Cl₂ / 48 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(98)00232-4