2,4-dihydroxybenzoic acid isopropyl ester

Base Information

• Chemical Name: 2,4-dihydroxybenzoic acid isopropyl ester
• CAS No.: 1368224-26-3
• Molecular Formula: C₁₀H₁₂O₄
• Molecular Weight: 196.203
• Mol file: 1368224-26-3.mol

Synonyms:2,4-dihydroxybenzoic acid isopropyl ester

Chemical Property of 2,4-dihydroxybenzoic acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2,4-dihydroxybenzoic acid isopropyl ester

There total 2 articles about 2,4-dihydroxybenzoic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-hydroxysalicylic acid (89-86-1) + isopropyl bromide (75-26-3) → 2,4-dihydroxybenzoic acid isopropyl ester (1368224-26-3)

Guidance literature:

4-hydroxysalicylic acid; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.666667h; Inert atmosphere;

isopropyl bromide; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1080/00397911.2012.681827

Reference yield: 27.0%

4-hydroxysalicylic acid (89-86-1) + isopropyl alcohol (67-63-0,8013-70-5) → 2,4-dihydroxybenzoic acid isopropyl ester (1368224-26-3)

Guidance literature:

With thionyl chloride; at 0 ℃; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2012.05.019

Reference yield: 99.0%

triisopropylsilyl chloride (13154-24-0) + 2,4-dihydroxybenzoic acid isopropyl ester (1368224-26-3) → 2-hydroxy-4-(triisopropylsilyloxy)benzoic acid isopropyl ester (1644064-14-1)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.3762/bjoc.10.112

upstream raw materials:

4-hydroxysalicylic acid

isopropyl alcohol

isopropyl bromide

Downstream raw materials:

C₃₆H₄₆O₂₁

2-hydroxy-4-(triisopropylsilyloxy)benzoic acid isopropyl ester

5-hydroxy-2-(isopropoxycarbonyl)phenyl-β,D-glucoside

C₂₄H₃₀O₁₃