4-(4-but-2-ynyloxy-phenylsulfanyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Base Information

Chemical Name:4-(4-but-2-ynyloxy-phenylsulfanyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester
CAS No.:1025986-88-2
Molecular Formula:C₂₃H₃₁NO₅S
Molecular Weight:433.569
Hs Code.:

4-(4-but-2-ynyloxy-phenylsulfanyl)-piperidine-1,4-dicarboxylic acid 1-<i>tert</i>-butyl ester 4-ethyl ester

Synonyms:4-(4-but-2-ynyloxy-phenylsulfanyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

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Chemical Property of 4-(4-but-2-ynyloxy-phenylsulfanyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

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Technology Process of 4-(4-but-2-ynyloxy-phenylsulfanyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

There total 3 articles about 4-(4-but-2-ynyloxy-phenylsulfanyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 287201-93-8
bis(4-but-2-ynyloxyphenyl)disulfide

: 1025986-88-2
4-(4-but-2-ynyloxy-phenylsulfanyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:: 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate; With tert.-butyl lithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 0.666667h;

bis(4-but-2-ynyloxyphenyl)disulfide; In tetrahydrofuran; hexane; at 25 ℃; for 1.5h;
DOI:10.1021/jm040086x

Reference yield:

: 286459-94-7
4-but-2-ynyloxybenzenesulfonyl chloride

: 1025986-88-2
4-(4-but-2-ynyloxy-phenylsulfanyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: PPh₃; DMF / CH₂Cl₂ / 2 h

2.1: HCl / dimethylsulfoxide / 18 h

3.1: t-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 - 0 °C

3.2: 0.55 g / tetrahydrofuran; hexane / 1.5 h / 25 °C

With hydrogenchloride; tert.-butyl lithium; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm040086x

Reference yield:

: 287201-95-0
4-but-2-ynyloxy-benzenethiol

: 1025986-88-2
4-(4-but-2-ynyloxy-phenylsulfanyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCl / dimethylsulfoxide / 18 h

2.1: t-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 - 0 °C

2.2: 0.55 g / tetrahydrofuran; hexane / 1.5 h / 25 °C

With hydrogenchloride; tert.-butyl lithium; In tetrahydrofuran; hexane; dimethyl sulfoxide;
DOI:10.1021/jm040086x