4,5-dihydro-3-(5-methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)-5-phenylpyrazol-1-carbothioamide

Base Information

• Chemical Name: 4,5-dihydro-3-(5-methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)-5-phenylpyrazol-1-carbothioamide
• CAS No.: 1338725-29-3
• Molecular Formula: C₂₀H₂₀N₆S
• Molecular Weight: 376.485

Synonyms:4,5-dihydro-3-(5-methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)-5-phenylpyrazol-1-carbothioamide

Chemical Property of 4,5-dihydro-3-(5-methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)-5-phenylpyrazol-1-carbothioamide

Chemical Property:

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Technology Process of 4,5-dihydro-3-(5-methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)-5-phenylpyrazol-1-carbothioamide

There total 4 articles about 4,5-dihydro-3-(5-methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)-5-phenylpyrazol-1-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(E)-1-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-3-phenylprop-2-en-1-one (1207996-15-3) + thiosemicarbazide (79-19-6) → 4,5-dihydro-3-(5-methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)-5-phenylpyrazol-1-carbothioamide (1338725-29-3)

Guidance literature:

(E)-1-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-3-phenylprop-2-en-1-one; thiosemicarbazide; In ethanol; at 90 ℃;

With potassium hydroxide; In ethanol; water; at 20 ℃; Reflux;

DOI:10.1002/jhet.706

Reference yield:

p-methylazidobenzene (2101-86-2) → 4,5-dihydro-3-(5-methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)-5-phenylpyrazol-1-carbothioamide (1338725-29-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 11 h / 0 °C / Reflux

2.1: potassium hydroxide / ethanol; water / 6 h / 25 °C / Cooling with ice

3.1: ethanol / 90 °C

3.2: 20 °C / Reflux

With sodium methylate; potassium hydroxide; In methanol; ethanol; water; 2.1: Claisen Schmidt condensation;

DOI:10.1002/jhet.706

Reference yield:

acetylacetone (123-54-6,81235-32-7) → 4,5-dihydro-3-(5-methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)-5-phenylpyrazol-1-carbothioamide (1338725-29-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 11 h / 0 °C / Reflux

2.1: potassium hydroxide / ethanol; water / 6 h / 25 °C / Cooling with ice

3.1: ethanol / 90 °C

3.2: 20 °C / Reflux

With sodium methylate; potassium hydroxide; In methanol; ethanol; water; 2.1: Claisen Schmidt condensation;

DOI:10.1002/jhet.706

upstream raw materials:

(E)-1-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-3-phenylprop-2-en-1-one

thiosemicarbazide

p-methylazidobenzene

acetylacetone

Downstream raw materials:

2-(3-(5-methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazole

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