4-amino-5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxyphenyl pivalate

Base Information

Chemical Name:4-amino-5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxyphenyl pivalate
CAS No.:1245618-65-8
Molecular Formula:C₃₂H₃₉N₃O₆
Molecular Weight:561.678
Hs Code.:

Synonyms:4-amino-5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxyphenyl pivalate

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Chemical Property of 4-amino-5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxyphenyl pivalate

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Technology Process of 4-amino-5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxyphenyl pivalate

There total 5 articles about 4-amino-5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxyphenyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1245618-64-7
5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxy-4-nitrophenyl pivalate

: 1245618-65-8
4-amino-5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxyphenyl pivalate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; Inert atmosphere;
DOI:10.1016/j.bmc.2010.06.057

Reference yield:

: 82925-01-7
1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[2-(4-nitrophenyl)ethyl]-isoquinoline

: 1245618-65-8
4-amino-5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxyphenyl pivalate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C

3: palladium on activated charcoal; hydrogen / methanol; ethyl acetate / 16 h / 20 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 82925-02-8
4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine

: 1245618-65-8
4-amino-5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxyphenyl pivalate

Guidance literature:: Multi-step reaction with 2 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C

2: palladium on activated charcoal; hydrogen / methanol; ethyl acetate / 16 h / 20 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; ethyl acetate; N,N-dimethyl-formamide;