5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxy-4-nitrophenyl pivalate

Base Information

Chemical Name:5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxy-4-nitrophenyl pivalate
CAS No.:1245618-64-7
Molecular Formula:C₃₂H₃₇N₃O₈
Molecular Weight:591.661
Hs Code.:

Synonyms:5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxy-4-nitrophenyl pivalate

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Chemical Property of 5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxy-4-nitrophenyl pivalate

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Technology Process of 5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxy-4-nitrophenyl pivalate

There total 5 articles about 5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxy-4-nitrophenyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1245618-63-6
5-[(2,2-dimethylpropanoyl)oxy]-4-methoxy-2-nitrobenzoic acid

: 82925-02-8
4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine

: 1245618-64-7
5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxy-4-nitrophenyl pivalate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield:

: C₁₃H₁₄ClNO₆

: 82925-02-8
4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine

: 1245618-64-7
5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxy-4-nitrophenyl pivalate

Guidance literature:: With triethylamine; In tetrahydrofuran;
DOI:10.1016/j.bmc.2010.06.057

Reference yield:

: 82925-01-7
1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[2-(4-nitrophenyl)ethyl]-isoquinoline

: 1245618-64-7
5-(4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]anilinocarbonyl)-2-methoxy-4-nitrophenyl pivalate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;