tert-butyl 4-hydroxy-4-(4-(trifluoromethyl)phenyl)-1-piperidinecarboxylate

Base Information

Chemical Name:tert-butyl 4-hydroxy-4-(4-(trifluoromethyl)phenyl)-1-piperidinecarboxylate
CAS No.:1191240-41-1
Molecular Formula:C₁₇H₂₂F₃NO₃
Molecular Weight:345.362
Hs Code.:

Synonyms:tert-butyl 4-hydroxy-4-(4-(trifluoromethyl)phenyl)-1-piperidinecarboxylate

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Chemical Property of tert-butyl 4-hydroxy-4-(4-(trifluoromethyl)phenyl)-1-piperidinecarboxylate

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Technology Process of tert-butyl 4-hydroxy-4-(4-(trifluoromethyl)phenyl)-1-piperidinecarboxylate

There total 5 articles about tert-butyl 4-hydroxy-4-(4-(trifluoromethyl)phenyl)-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 501374-30-7
5,5-dimethyl-2-(4-trifluoromethyl-phenyl)-[1,3,2]dioxaborinane

: 1191240-41-1
tert-butyl 4-hydroxy-4-(4-(trifluoromethyl)phenyl)-1-piperidinecarboxylate

Guidance literature:: With C₆₂H₇₄Cl₂N₄Pd₂S₂; potassium carbonate; In toluene; at 120 ℃; for 18h; Inert atmosphere; Sealed tube;
DOI:10.1002/cctc.202001464

Reference yield: 84.0%

: 402-43-7
p-trifluoromethylphenyl bromide

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1191240-41-1
tert-butyl 4-hydroxy-4-(4-(trifluoromethyl)phenyl)-1-piperidinecarboxylate

Guidance literature:: p-trifluoromethylphenyl bromide; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1021/acs.jmedchem.9b00864

Reference yield: 76.0%

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 501374-30-7
5,5-dimethyl-2-(4-trifluoromethyl-phenyl)-[1,3,2]dioxaborinane

: 1191240-41-1
tert-butyl 4-hydroxy-4-(4-(trifluoromethyl)phenyl)-1-piperidinecarboxylate

Guidance literature:: With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium tert-butylate; chlorobenzene; cesium fluoride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; In toluene; at 80 ℃; for 0.5h; Inert atmosphere;
DOI:10.1039/c1cc10826c